MR DCE Ktrans值在喉软骨病变的临床价值  

Dynamic Contrast-Enhanced MRI for Differentiating Laryngeal Cartilage Lesions

作　　者：于金芬 王林省 李传亭[2] 孙立新 YU Jinfen;WANG Linsheng;LI Chuanting;SUN Lixin(Department of Medical Imaging Center,Shandong Second Provincial General Hospital,Jinan250021,China;Department of Medical Imaging Center,Shandong Provincial Hospital,Jinan250021,China)

机构地区：[1]山东省第二人民医院医学影像中心,济南250021 [2]山东省立医院医学影像中心,济南250021

出　　处：《中国医学计算机成像杂志》2022年第5期466-471,共6页Chinese Computed Medical Imaging

基　　金：山东省医药卫生科技发展计划项目(202009011530)。

摘　　要：目的:探讨磁共振动态强化扫描参数容量转移常数(Ktrans)值在不同类型喉软骨病变的临床价值。方法:纳入3组病例,其中17例咽喉部良性病变为良性组,18例行颈部放射治疗为放疗组,17例咽喉部恶性病变为恶性组,另以27名健康成人志愿者为对照组。所有图像均在MR扫描仪(MR750,GE,USA)上获得。所有MRI图像由2名经验丰富的影像诊断医生采用双盲法分析。基于病理组织学诊断,受试者工作特征(ROC)曲线分析得出各组的诊断临界值、灵敏度、特异度和ROC曲线下面积。结果:Ktrans值在4组间差异均有统计学意义(P<0.005),其中恶性组的Ktrans值最大,正常组的最小,分别为(0.868 1±0.303 4)min^(-1)和(0.298 6±0.074 8)min^(-1)。各组的Ktrans值诊断截点分别为:正常组Ktrans≤0.39min^(-1),恶性组Ktrans>0.713min^(-1),良性组0.39min^(-1)<Ktrans≤0.511min和放疗组0.511min<Ktrans≤0.713min。结论:Ktrans在定量定性地鉴别不同类型喉软骨病变中有重要的临床价值。Purpose:To explore the value of dynamic contrast-enhanced(DCE)-MRI in the assessment of laryngeal cartilage invasion.Methods:Seventeen patients with benign lesion of laryngopharynx,18 with history of neck radiotherapy and 17 with malignant lesion of laryngopharynx were collected in this study.Twenty-seven healthy volunteers were selected as control group.Routine MRI and DCE-MRI were acquired on a 3.0 T MR scanner(MR750,GE,USA).All images were evaluated by two independent experienced radiologists with double blinded method.Cut-off values,sensitivity,specificity and area under the curve(AUC)were calculated with receiveroperating characteristic(ROC)curve analysis based on pathologic findings of surgically resected specimens.Results:There was a significant difference of volume transfer constant(Ktrans)among normal laryngeal cartilage,laryngeal cartilage with benign lesions,laryngeal cartilage after radiotherapy and malignant lesions of laryngeal cartilage(P<0.005).The malignant lesions of laryngeal cartilage were with the highest Ktrans value[(0.8681±0.3034)min^(-1)]and the normal laryngeal cartilage were with the lowest Ktrans value[(0.2986±0.0748)min^(-1)].The ranges of Ktrans value of normal laryngeal cartilage,malignant lesions,benign lesions and laryngeal cartilage after radiotherapy were less than or equal to 0.39 min^(-1),greater than 0.713 min^(-1),0.39 to 0.511 min^(-1) and 0.511 to 0.713 min^(-1),respectively.Conclusions:Ktrans has important clinical value in differentiating different types of laryngeal cartilage lesions quantitatively and qualitatively.

关 键 词：喉软骨病变 动态强化扫描 磁共振成像 容量转移常数 

分 类 号：R445.2[医药卫生—影像医学与核医学]