中药调控细胞凋亡抗动脉粥样硬化研究进展  

Chinese Medicine Regulates Apoptosis to Treat Atherosclerosis:A Review

作　　者：任正肖 朱庆均[1] 王彦芳[1] 李紫薇 张颖颖[1] 车萍[1] REN Zhengxiao;ZHU Qingjun;WANG Yanfang;LI Ziwei;ZHANG Yingying;CHE Ping(Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东中医药大学,济南250355

出　　处：《中国实验方剂学杂志》2022年第22期214-223,共10页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81673843);国家重大新药创制科技重大专项2017ZX09301030-005。

摘　　要：动脉粥样硬化(AS)是一种慢性多因素血管性疾病,是心血管疾病的重要病理基础,多发于中老年,患者死亡率较高。细胞凋亡是机体一种自发性程序性死亡,病理状态下,内皮细胞(VEC)、血管平滑肌细胞(VSMCs)和巨噬细胞凋亡是AS发生和发展的关键因素,VEC凋亡可能是促进AS病变的形成和发展的早期事件,而随后的VSMCs和巨噬细胞凋亡则加速AS不稳定斑块形成,在AS疾病晚期发挥重要作用。因此细胞凋亡可能为治疗AS疾病提供新的靶点。而越来越多的证据表明,中药能够通过调节细胞凋亡因子及凋亡相关信号通路在治疗AS中发挥重要作用。但目前从细胞凋亡探讨中药治疗AS研究缺乏系统总结。因此该文通过查阅国内外相关文献,系统汇总了细胞凋亡的分子机制、重点从线粒体凋亡途径、死亡受体凋亡途径、内质网应激凋亡途径及相关细胞凋亡信号通路,探讨了细胞凋亡在AS中的作用,并对中药通过调控细胞凋亡抗AS的作用及机制进行梳理和总结,旨在为AS的治疗及新的药物研发提供一定的理论依据。Atherosclerosis(AS)is a chronic multifactorial vascular disease and a major pathological basis of cardiovascular diseases.It mainly occurs in the middle-aged and elderly and causes high mortality.Apoptosis is a form of spontaneous programmed death.Under pathological conditions,the apoptosis of vascular endothelial cells(VECs),vascular smooth muscle cells(VSMCs),and macrophages is the key factor of the occurrence and development of AS.The apoptosis of VECs may be an early event that promotes the formation and progression of AS lesions,while the subsequent apoptosis of VSMCs and macrophages accelerates the formation of AS unstable plaques and plays a key role in the late stage of AS.Therefore,apoptosis may provide a new target for the treatment of AS.Increasing evidence has demonstrated that Chinese medicine plays a positive role in the treatment of AS by regulating apoptosis factors and apoptosis-associated signaling pathways.However,the studies about the treatment of AS with Chinese medicine from apoptosis have not been systematically reviewed.Therefore,we reviewed the relevant literature and systematically summarized the molecular mechanisms of apoptosis.Specifically,we focused on mitochondrial apoptosis pathway,death receptor apoptosis pathway,endoplasmic reticulum stress apoptosis pathway and explored the role of apoptosis in AS.Further,we reviewed the progress in the role and mechanism of Chinese medicine in regulating apoptosis against AS,aiming to provide a theoretical basis for the treatment of AS and the development of drugs.

关 键 词：细胞凋亡 血管内皮细胞 血管平滑肌细胞 巨噬细胞 动脉粥样硬化 中药 

分 类 号：R2-0[医药卫生—中医学] R22R285.5R284R33