海洋动物来源糖胺聚糖生物活性研究进展  

Advances in bioactivity of glycosaminoglycans derived from marine animals

作　　者：王培培 张真庆[4] 迟连利[5] 于广利[2,3] WANG Pei-pei;ZHANG Zhen-qing;CHI Lian-li;YU Guang-li(College of Food Science and Technology,Shanghai Ocean University,Shanghai 201306,China;Key Laboratory of Marine Drugs,Ministry of Education,Shandong Key Laboratory of Glycoscience and Glycotechnology,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China;Laboratory for Marine Drugs and Bioproducts of Qingdao Pilot National Laboratory for Marine Science and Technology,Qingdao 266237,China;College of Pharmaceutical Sciences,Soochow University,Suzhou 215123,China;Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology,Shandong University,Qingdao 266200,China)

机构地区：[1]上海海洋大学食品学院,海201306 [2]中国海洋大学海洋药物教育部重点实验室,山东省糖科学与糖工程重点实验室,医药学院,山东青岛266003 [3]青岛海洋科学与技术试点国家实验室海洋药物与生物制品功能实验室,山东青岛266237 [4]苏州大学医学部药学院,江苏苏州215123 [5]山东大学山东省糖化学与生物学重点实验室,山东青岛266200

出　　处：《中国海洋药物》2022年第5期82-90,共9页Chinese Journal of Marine Drugs

基　　金：国家自然科学基金重大项目(81991522);山东省泰山学者攀登计划(TSPD20210304);山东省糖化学与生物学重点实验室开放课题(2021CCG03)资助。

摘　　要：糖胺聚糖具有抗凝、抗血栓、抗肿瘤、抗炎、神经保护、调节肠道菌群及预防和治疗代谢性疾病等多种生物活性,在生物医药、功能食品及日化用品等领域具有广阔应用前景。我国海洋动物资源丰富,所含糖胺聚糖含量高且结构独特,是糖胺聚糖类新药开发的重要资源。对海洋动物中糖胺聚糖的来源、结构特征、生物活性及潜在应用价值进行综述,以期为海洋动物来源糖氨聚糖的高值化利用提供科学依据。Glycosaminoglycans have various biological activities such as anticoagulant, antithrombotic,antitumor, antidiabetic, anti-inflammatory, neuroprotection, intestinal microbiota regulation, prevention and treatment of metabolic diseases, which have a broad application prospect in the field of biomedicines,functional food and daily use cosmetics. Marine animal resources are rich in our country. Abundant glycosaminoglycans from marine animals with unique structure are the important resources for new drug development. Here, the source, structural characteristics, biological activities and potential application values of glycosaminoglycans from marine animals are reviewed. These will provide scientific basis for the high value utilization of glycosaminoglycans from marine animals.

关 键 词：海洋动物 糖胺聚糖 结构特征 生物活性 

分 类 号：R931.77[医药卫生—生药学]