Catalytic Enantioselective Construction of 6-4 Ring-Junction All-Carbon Stereocenters and Mechanistic Insights  

作　　者：Jia-Yin Wang Chen-Long Li Ting Xu Meng-Fan Li Wen-Juan Hao Shu-Jiang Tu Jianyi Wang Guigen Li Zhi-Xiang Yu Bo Jiang 

机构地区：[1]School of Chemistry&Materials Science,Jiangsu Normal University,Xuzhou,Jiangsu 221116,China [2]College of Chemistry,Peking University,Beijing 100871,China [3]Medical College,Guangxi University,Nanning,Guangxi 530004,China [4]Institute of Chemistry&Biomedical Sciences,Nanjing University,Nanjing,Jiangsu 210093,China [5]Department of Chemistry and Biochemistry,Texas Tech University,Lubbock,Texas 79409-1061,United States

出　　处：《Chinese Journal of Chemistry》2022年第15期1767-1776,共10页中国化学（英文版）

基　　金：We are grateful for financial support from the NSFC(Nos.21871112,21971090,and 21933003).

摘　　要：Comprehensive Summary Developing reactions for the synthesis of 6-6-4 and 6-4 carbocyclic scaffolds with a chiral quaternary center at the bridgehead position is highly desired,considering the existence of such skeletons in natural products with biological activities and the potential of using these molecules for downstream studies in chemical biology and medicinal chemistry.Report here is accessing these target skeletons with high chemo-,regio-and enantio-selectivities through Pd(ll)/chiral N,N'-disulfonyl bisimidazoline(Bim)ligand-catalyzed asymmetric reaction of yne-allenones and arylboronic acids.

关 键 词：Asymmetric catalysis PALLADIUM Michael addition Chiral cyclobutenes Mechanism 

分 类 号：O62[理学—有机化学]