Alkaloid Dimers Isolated from Thalictrum baicalense Have Antitumor Activities  

作　　者：Jingjing Xue Yuetong Wang Fangshen Liu Hangao Yang Bin Lin Zhanlin Li Yongkui Jing Dahong Li Huiming Hua 

机构地区：[1]Key Laboratory of Structure-Based Drug Design&Discovery,Ministry of Education,Shenyang Pharmaceutical University,Shenyang,Liaoning 110016,China [2]School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang,Liaoning 110016,China [3]School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang,Liaoning 110016,China [4]Wuya College of Innovation,Shenyang Pharmaceutical University,Shenyang,Liaoning 110016,China

出　　处：《Chinese Journal of Chemistry》2022年第15期1831-1841,共11页中国化学（英文版）

基　　金：This work was supported by the National Natural Science Foundationof China(No.82173715).

摘　　要：Comprehensive Summary A pair of heterodimeric isoquinoline alkaloid enantiomers,(+)thaliberberine A,five new thalifaberine-type aporphine-benzylisoquinoline(ABl)alkaloids,thalicultratines M-Q,and thirteen known analogues were isolated from the roots of Thalictrum baicalense Turcz.ex Ledeb.The structures were determined by extensive spectroscopic methods and ECD calculations.Thaliberberine A featuring a novel carbon skeleton coupled by two different classes of isoquinoline alkaloids,protoberberine and phthalidoisoquinoline,represents the first natural product with the berberine skeleton substituted at C-6.Plausible biosynthetic routes of 1 are proposed.

关 键 词：Thalictrum baicalense Heterodimeric isoquinoline alkaloid Thalifaberine-type ABI alkaloids Antitumor activity Apoptosis 

分 类 号：O62[理学—有机化学]