FBW7抑制肿瘤生长的机制及其研究进展  

Mechanism underlying FBW7 inhibition of tumor growth and research advances

作　　者：王新安 徐成党 吴登龙[1] Wang Xinan;Xu Chengdang;Wu Denglong(Department of Urology,Tongji Hospital,School of Medicine,Tongji University,Shanghai 200065,China)

机构地区：[1]同济大学附属同济医院泌尿外科,上海200065

出　　处：《泌尿外科杂志（电子版）》2022年第2期39-44,共6页Journal of Urology for Clinicians(Electronic Version)

摘　　要：肿瘤抑制基因FBW7突变体在多种肿瘤中高表达。FBW7通过靶向降解多种原癌蛋白如Brg1、Cyclin E、C-myc、Notch、c-Jun、Mcl-1和SREBP等调控细胞增殖、凋亡及能量代谢等多种生物学过程中的关键分子而发挥肿瘤抑制作用。本文将从FBW7靶向降解底物抑制肿瘤生长和FBW7突变、FBW7靶向降解底物突变和的FBW7自身紊乱三方面探究FBW7抑癌作用的消失进行综述。The high expression of the tumor suppressor mutant,FBW7,has been confirmed in a variety of tumors.FBW7 targets key proteins in various biological processes,such as Brg1,cyclin E,C-myc,Notch,c-Jun,Mcl-1,and SREBP,to achieve tumor inhibition.In this article we review the three ways in which the FBW7 tumor suppress or effect is lost:FBW7-targeted degradation of substrates to inhibit tumor growth and FBW7 mutation;FBW7-targeted degradation of substrate mutations;and FBW7-ass-sociated disorders.

关 键 词：FBW7 泛素化 肿瘤抑制基因 

分 类 号：R37[医药卫生—病原生物学]