β_(2)-MG、FGF 23、SCr在慢性肾衰竭患者中的水平及对预后的评估作用分析  

Analysis of the Level ofβ_(2)-MG,FGF 23 and SCr in Patients with Chronic Renal Failure and Their Prognostic Evaluation

作　　者：邱强 宋洁 张月 QIU Qiang;SONG Jie;ZHANG Yue(Department of Nephrology,Shunyi District Hospital of Beijing,Beijing 101312,China)

机构地区：[1]北京市顺义区医院肾内科,北京101312

出　　处：《解放军医药杂志》2022年第10期58-61,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：北京市教育委员会科技计划(KM20170025019)。

摘　　要：目的讨论β_(2)-微球蛋白(β_(2)-MG)、成纤维细胞生长因子23(FGF 23)、血清肌酐(SCr)在慢性肾衰竭(CRF)中的水平及对预后的评估作用。方法选取2018年6月—2020年8月收治的154例CRF作为观察组,另选取同期121名体检健康者作为对照组,比较2组β_(2)-MG、FGF 23、SCr水平,不同分期CRF患者β_(2)-MG、FGF 23、SCr水平,分析影响CRF患者预后不良的因素。结果观察组β_(2)-MG、FGF 23、SCr水平明显高于对照组(P<0.01)。CKD 5期患者血清β_(2)-MG、FGF 23、SCr水平均高于CKD 3、4期患者,CKD 4期患者血清β_(2)-MG、FGF 23、SCr水平高于CKD 3期患者(P<0.05)。经多因素Logistic回归分析可知,心血管疾病、β_(2)-MG、FGF 23、SCr为CRF患者预后不良的独立危险因素(P<0.05,P<0.01)。结论CRF患者β_(2)-MG、FGF 23、SCr水平升高,且随着病情发展三者水平呈上升趋势,三者检测有助于评估CRF患者预后情况。Objective To discuss the levels of β_(2)-microglobulin(β_(2)-MG),fibroblast growth factor 23(FGF 23)and serum creatinine(SCr)in chronic renal failure(CRF)and their prognostic significance.Methods In total,154 patients with CRF admitted from June 2018 to August 2020 were selected as the observation group,and 121 healthy people undergoing physical examination during the same period were selected as the control group.β_(2)-MG,FGF 23,SCr levels in the two groups as well as in patients in different stages were compared.The factors affecting the prognosis of CRF patients were analyzed.Results The levels of β_(2)-MG,FGF 23 and SCr of observation group were significantly higher than those in the control group(P<0.01).Serum β_(2)-MG,FGF 23 and SCr levels were higher in patients with chronic kidney disease stage 5(CKD 5)than in patients with CKD 3 and CKD 4,and higher in patients with CKD 4 than in patients with CKD 3(P<0.05).Multivariate Logistic regression analysis showed that cardiovascular disease,β_(2)-MG,FGF 23 and SCr were independent risk factors for poor prognosis of CRF patients(P<0.05,P<0.01).Conclusion The levels ofβ_(2)-MG,FGF 23 and SCr of CRF patients increased,and the three levels showed an upward trend with the development of the disease.The detection of the three levels is helpful to evaluate the prognosis of patients.

关 键 词：肾功能衰竭 慢性 β_(2)-微球蛋白 成纤维细胞生长因子23 血清肌酐 预后评估 

分 类 号：R692.5[医药卫生—泌尿科学]