痱子粉中氧化锌含量测定方法的改进  

Improvement of Determination Method of Zinc Oxide in Miliaria Powder

作　　者：吴坤林 杨丽娜[1] 王庆芬[1] WU Kun-lin;YANG Li-na;WANG Qing-fen(Department of Pharmacy,The 909th Hospital/Dongnan Hospital of Xiamen University,Zhangzhou 363000,China)

机构地区：[1]联勤保障部队第九○九医院/厦门大学附属东南医院药剂科,福建漳州363000

出　　处：《海峡药学》2022年第10期53-55,共3页Strait Pharmaceutical Journal

摘　　要：目的 对痱子粉中氧化锌含量测定方法进行改进。方法 采用二甲酚橙为指示剂,醋酸-醋酸铵(p H=6.0)为缓冲液,乙二胺四醋酸二钠(0.05 mol·L^(-1))为配位剂的方法直接测定。结果 用改进后的含量测定方法简化了一系列操作步骤,滴定终点突跃明显,且滑石粉对试验结果不产生干扰,标准曲线回归方程为y=239.0x+0.278,r=1.0000,表明氧化锌的取样量在0.06~0.14 g范围内,与乙二胺四醋酸二钠滴定液(0.05 mol·L^(-1))的消耗体积具有良好的线性关系,平均重复性RSD为0.35%,平均加样回收率为99.76%(RSD=0.26%)。结论 该试验所采用的含量测定方法较原方法简单,结果更准确、可靠,可用于痱子粉中氧化锌含量的测定。OBJECTIVE To improve the method for the content determination of zinc oxide in miliaria powder.METHODS Xylenol orange was used as indicator,acetic acid ammonium acetate (p H=6.0) was used as buffer and ethylenediamine tetraacetic acid disodium (0.05 mol·L^(-1)) was used as complexing agent.RESULTS The standard curve regression equation was y=239.0x+0.278,r=1.0000.Zinc oxide showed good linear relation in the range of 0.06-0.14 g with the titration(0.05 mol·L^(-1)).The average repeatability RSD was 0.35%.The average recovery rate was 99.76%(RSD=0.26%).CONCLUSION The method is simple,accurate and reliable,and can be used for the determination of zinc oxide in miliaria powder.

关 键 词：痱子粉 氧化锌 滑石粉 配位滴定法 EDTA 含量测定 

分 类 号：R927[医药卫生—药学]