诱导类凋亡的抗肿瘤化合物的研究进展  

Advance in Research on Compounds with Paraptosis Induction Effect

作　　者：陈策 孙小龙 谢琦琦 林修辉 潘莉分 胡琼莹[1,2] CHEN Ce;SUN Xiao-long;XIE Qi-qi;LIN Xiu-hui;PAN Li-fen;HU Qiong-ying(Schol f Medicine,Taizhou University,Taizhou 318000,China;Hebei North University,Zhangjiakou 075000,China)

机构地区：[1]台州学院医学院,浙江台州318000 [2]河北北方学院,河北张家口075000

出　　处：《中国药学杂志》2022年第18期1512-1517,共6页Chinese Pharmaceutical Journal

基　　金：浙江省基础公益项目资助(LGF21H280002);浙江省公益技术应用研究项目资助(2016C37143)。

摘　　要：如何克服因肿瘤细胞凋亡缺失或受阻出现的肿瘤耐药问题,是目前肿瘤治疗过程中亟需解决的难题之一,发现新的非凋亡细胞程序性死亡方式并运用相应作用机制的药物可作为肿瘤治疗的一种新策略。类凋亡是一种新的程序性细胞死亡方式,通常伴随着由内质网应激、蛋白酶体抑制或离子稳态失衡导致的细胞器肿胀,并且为非caspase依赖性的。笔者对细胞类凋亡的作用机制和诱导细胞类凋亡的化合物进行综述,并对该领域未来的研究方向进行探讨,以期为肿瘤治疗提供一种新思路。How to overcome the problem of drug resistance to tumors caused by the loss or obstruction of tumor cell apoptosis is one of the urgent problems to be solved in cancer treatment.It could be a new strategy for cancer treatment to discover a new programmed cell death of non-apoptosis and utilize the corresponding drugs with action mechanism described above.Paraptosis is a kind of new programmed cell death,which is usually accompanied by cytoplasmic vacuolation derived from endoplasmic reticulum stress,proteasome inhibition or ion homeostasis imbalance,and which is caspase independent.The current review outlined the mechanism of cell paraptosis and the compounds that induce cell paraptosis.Then,the trend in this field was discussed to offer a new idea for cancer treatment.

关 键 词：类凋亡 凋亡 化合物 抗肿瘤 内质网应激 

分 类 号：R961[医药卫生—药理学] R730.5[医药卫生—药学]