氨氯地平贝那普利片对急性心肌梗死合并高血压患者外周血内皮微粒以及IL-6、IL-17水平的影响  

Effects of Amlodipine-Benazepril Tablets on Peripheral Blood Endothelial Microparticles and IL-6 and IL-17 Levels in Patients with Acute Myocardial Infarction Complicated with Hypertension

作　　者：邓毅凡 刘娟[1] 孙珣 戴承晔 徐笑挺 何胜虎[1] 张晶[1] DENG Yi-fan;LIU Juan;SUN Xun;DAI Cheng-ye;XU Xiao-ting;HE Sheng-hu;ZHANG Jing(Clinical Medical College,Yangzhou University,Department of Cardiovascular Medicine,Northern Jiangsu People's Hospital of Jiangsu Province,Yangzhou 225001,China;The Yangzhou School of Clinical Medicine of Dalian Medical University,Yangzhou 225001,China)

机构地区：[1]扬州大学临床医学院,江苏省苏北人民医院心内科,江苏扬州225001 [2]大连医科大学扬州临床医学院,江苏扬州225001

出　　处：《中国药学杂志》2022年第18期1571-1574,共4页Chinese Pharmaceutical Journal

基　　金：江苏省卫生健康委科研课题资助(Z2018032);扬州市重点研发(社会发展)项目资助(YZ2020103);2021年江苏省研究生科研与实践创新项目资助(SJCX21-1647)。

摘　　要：目的探讨氨氯地平贝那普利片对急性心肌梗死合并高血压患者外周血内皮微粒(endothelial microparticles,EMPs)以及白介素-6(interleukin-6,IL-6)、白介素-17(interleukin-17,IL-17)水平的影响。方法选取我院急性心肌梗死合并高血压病患共计208人,随机分为研究组和对照组予以不同降压方案,其中对照组106例选用苯磺酸氨氯地平片自由联合其他种类降压药物,研究组102例选用氨氯地平贝那普利片治疗,检测两组患者治疗前后心室质量指数、IL-6、IL-17以及EMPs水平,并定期随访统计患者治疗期间主要心血管不良事件(MACE)发生率、药物不良反应以及服药依从性。结果2组病患经过上述治疗后,外周血IL-6、IL-17以及EMPs水平均有所下降;与对照组相比,研究组病患治疗后IL-6、IL-17以及EMPs水平下降幅度更大(P<0.05),MACE发生率更低,服药依从性更好(P<0.05),不同治疗方案的药物不良反应相比无统计学差异(P>0.05)。结论氨氯地平贝那普利片能够明显降低急性心肌梗死合并高血压患者IL-6、IL-17以及EMPs水平,改善患者预后,服药依从性更好,值得推荐于临床使用。OBJECTIVE To investigate the effects of amlodipine-benazepril tablets on peripheral blood endothelial microparticles(EMPs),IL-6 and IL-17 levels in patients with acute myocardial infarction complicated with hypertension.METHODS Selecting hospital diagnosis for patients with acute myocardial infarction,hypertension,a total of 208 people,will be randomly divided into two groups,control group 106 cases taking benzene sulfonic acid amlodipine free joint other antihypertensive drugs,study group 102 patients were treated with amlodipine-benazepril tablets.We detected of the groups before and after treatment in patients with ventricular mass index,IL-6,IL-17 and EMPs level.The incidence of major adverse cardiovascular events(MACE),adverse drug reactions,and medication compliance during treatment were analyzed during regular follow-up.RESULTS The levels of Il-6,IL-17 and EMPs decreased in both groups after treatment.Compared with the control group,the levels of IL-6,IL-17 and EMPs in the study group decreased significantly after treatment(P<0.05),the incidence of MACE was lower,and medication compliance was better(P<0.05).There was no statistical difference in adverse drug reactions between 2 groups(P>0.05).CONCLUSION Amlodipine-benazepril tablets can significantly reduce the levels of IL-6,IL-17 and EMPs in patients with acute myocardial infarction complicated with hypertension,improve the prognosis of patients with better medication compliance,which is worth recommending for clinical use.

关 键 词：急性心肌梗死 高血压 内皮微粒 白介素-6 白介素-17 

分 类 号：R969[医药卫生—药理学]