米非司酮联合依沙吖啶在瘢痕子宫中期妊娠引产中的应用效果及安全性  

Application effect and safety of mifepristone combined with ethacridine in midtrimester pregnancy induced labor of scar uterus

作　　者：张楚伟 张慧 ZHANG Chuwei;ZHANG Hui(Xianyang Rainbow Hospital,Xianyang 712000,China)

机构地区：[1]咸阳彩虹医院,陕西咸阳712000

出　　处：《临床医学研究与实践》2022年第34期84-87,共4页Clinical Research and Practice

摘　　要：目的探讨米非司酮联合依沙吖啶在瘢痕子宫中期妊娠引产中的应用效果及安全性。方法选取2019年2月至2020年3月我院妇产科接收的50例瘢痕子宫中期终止妊娠患者作为研究对象,按照随机抽签方式将其分为参照组(25例,依沙吖啶治疗)和试验组(25例,米非司酮联合依沙吖啶治疗)。比较两组的引产效果。结果试验组的宫缩发动时间、胎儿排出时间、引产时间、住院时间均短于参照组,引产出血量少于参照组,差异具有统计学意义(P<0.05)。试验组的胎盘黏膜残留、胎盘粘连、软产道损伤发生率均显著低于参照组,差异具有统计学意义(P<0.05)。引产后,试验组的白细胞介素-6(IL-6)、C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平低于参照组,白细胞分化抗原4阳性(CD4+)、自然杀伤细胞(NK)高于参照组,差异具有统计学意义(P<0.05)。两组的引产成功率比较,差异无统计学意义(P>0.05);试验组的清宫率低于参照组,差异具有统计学意义(P<0.05)。试验组的复潮时间早于参照组,首次经期持续时间长于参照组,差异具有统计学意义(P<0.05)。结论米非司酮联合依沙吖啶方案在瘢痕子宫中期妊娠引产中具备理想的引产结局,可改善患者的炎症、免疫指标水平,保证了引产的安全性,值得推广。Objective To investigate the application effect and safety of mifepristone combined with ethacridine in midtrimester pregnancy induced labor of scar uterus.Methods FromFebruary 2019 to March 2020,50 patients with mid-term pregnancy termination of scarred uterus received by obstetrics and gynecology department of our hospital were selected as the study objects.The patients were divided into reference group(25 cases,treated with ethacridine)and experimental group(25 cases,treated with mifepristone combined with ethacridine)according to random lottery.The induced labor effects of the two groups were compared.Results The uterine contraction start time,fetal discharge time,induction time and hospitalization time of the experimental group were shorter than those of the reference group,the amount of bleeding during induction was less than that of the reference group,and the differences were statistically significant(P<0.05).The incidences of placental mucosal residue,placental adhesion and soft birth canal injury in the experimental group were significantly lower than those in the reference group,and the differences were statistically significant(P<0.05).After induced labor,the levels of interleukin-6(IL-6),C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)in the experimental group were lower than those in the reference group,the cluster of differentiation 4 positive(CD4+),natural killer cell(NK)were higher than those in the reference group,and the differences were statistically significant(P<0.05).There was no significant difference in the success rate of induced labor between the two groups(P>0.05);the curettage rate of the experimental group was lower than that of the reference group,and the difference was statistically significant(P<0.05).The recovery time of the experimental group was earlier than that of the reference group,and the duration of the first menstrual period was longer than that of the reference group,and the differences were statistically significant(P<0.05).Conclusion Mifepristone combined w

关 键 词：瘢痕子宫 中期妊娠引产 米非司酮 依沙吖啶 

分 类 号：R719.3[医药卫生—妇产科学]