2型糖尿病合并MIS患者心室重构与血清CysC水平的相关性分析  

Correlation analysis between ventricular remodeling and serum CysC level in type 2 diabetes mellitus patients complicated with MIS

作　　者：李婷[1] 崔荣荣 LI Ting;CUI Rongrong(Shangluo Central Hospital,Shangluo 726000,China)

机构地区：[1]商洛市中心医院,陕西商洛726000

出　　处：《临床医学研究与实践》2022年第34期118-120,共3页Clinical Research and Practice

摘　　要：目的分析2型糖尿病(T2DM)合并代谢性炎症综合征(MIS)患者心室重构与血清胱抑素C(CysC)水平的相关性。方法选取2017年6月至2020年8月收治的104例T2DM合并MIS患者纳入MIS组,选取同期104例T2DM未合并MIS患者纳入无MIS组,再选取同期102例健康体检者纳入健康组。比较三组的心室重构情况;分析MIS组和无MIS组心室重构情况与CysC水平的相关性;比较三组的不良事件发生情况。结果MIS组的室间隔厚度(IVS)、左心室重量(LVM)、左室后壁厚度(LVPW)、左心室质量指数(LVMI)均大于无MIS组及健康组,差异具有统计学意义(P<0.05);三组的左心室舒张末期内径(LVDD)比较,差异无统计学意义(P>0.05)。Pearson相关性分析结果表明,IVS、LVM、LVPW、LVMI与CysC水平呈正相关(P<0.05);LVDD与CysC水平不相关(P>0.05)。MIS组的不良事件总发生率显著高于无MIS组,差异具有统计学意义(P<0.05)。结论T2DM合并MIS患者的心室重构情况与CysC水平存在相关性,进而影响不良事件发生率。Objective To analyze the correlation between ventricular remodeling and serum cystatin C(CysC)level in type 2 diabetes mellitus(T2DM)patients complicated with metabolic inflammatory syndrome(MIS).Methods A total of 104 T2DM patients complicated with MIS admitted from June 2017 to August 2020 were included in MIS group,104 T2DM patients without MIS during the same period were included in non-MIS group,and 102 healthy patients during the same period were included in healthy group.Ventricular remodeling was compared among the three groups;the correlation of ventricular remodeling and CysC level between the MIS group and the non-MIS group was analyzed;the incidence of adverse events was compared among the three groups.Results The intact ventricular septum(IVS),left ventricular mass(LVM),left ventricle post wall(LVPW)and left ventricular mass index(LVMI)of the MIS group were greater than those of the non-MIS group and the healthy group,and the differences were statistically significant(P<0.05);there was no significant difference in left ventricular end diastolic diameter(LVDD)among the three groups(P>0.05).The results of Pearson correlation analysis showed that IVS,LVM,LVPW,LVMI were positively correlated with CysC level(P<0.05);LVDD was not correlated with CysC level(P>0.05).The total incidence of adverse events in the MIS group was significantly higher than that in the non-MIS group,and the difference was statistically significant(P<0.05).Conclusion Ventricular remodeling in T2DM patients complicated with MIS is correlated with the level of CysC,which affects the incidence of adverse events.

关 键 词：2型糖尿病 代谢性炎症综合征 心室重构 胱抑素C 

分 类 号：R587[医药卫生—内分泌]