氨溴索联合纳洛酮对COPD呼吸衰竭合并肺部真菌感染患者的治疗效果  

Effect of ambroxol combined with naloxone on treatment of COPD respiratory failure patients complicated with pulmonary fungal infection

作　　者：侯思捷[1] 叶泉英 赖昕[3] 陈海生[4] 雷凯君[1] 陈晓兴[1] HOU Si-jie;YE Quan-ying;LAI Xin;CHEN Hai-sheng;LEI Kai-jun;CHEN Xiao-xing(Foshan Traditional Chinese Medicine Hospital,Foshan,Guangdong 528000,China;不详)

机构地区：[1]佛山市中医院药剂科,广东佛山528000 [2]佛山市科学技术学院医学院,广东佛山528000 [3]佛山市中医院呼吸科,广东佛山528000 [4]佛山市中医院检验科,广东佛山528000

出　　处：《中华医院感染学杂志》2022年第18期2757-2761,共5页Chinese Journal of Nosocomiology

基　　金：佛山市科技创新项目(1920001000297)。

摘　　要：目的 分析氨溴索联合纳洛酮对慢性阻塞性肺疾病(COPD)呼吸衰竭合并肺部真菌感染患者的治疗效果。方法 随机选取2020年5月-2021年5月佛山市中医院收治的COPD呼吸衰竭合并肺部真菌感染患者102例,双盲法分为对照组和研究组,分别给予纳洛酮单药及氨溴索联合治疗。治疗7 d后,检测两组患者动脉血气、肺功能及炎性因子指标,分析临床疗效。结果 治疗后,两组患者动脉血氧分压(PaO)、动脉血氧饱和度(SaO)、用力肺活量(FVC)、第一秒用力呼气量(FEV1)水平升高,血二氧化碳分压(PaCO)和肺动脉收缩压(PASP)水平降低,且研究组优于对照组(P<0.05);可溶性细胞间黏附分子(sICAM-1)、白细胞介素-6(IL-6)、C-反应蛋白(CRP)、铁调素(HEPC)水平均降低,胆碱酯酶(CHE)水平升高,且研究组优于对照组(P<0.05);研究组临床疗效总有效率为98.03%,对照组临床疗效总有效率为86.27%,两组比较差异有统计学意义(P<0.05)。结论 氨溴索联合纳洛酮治疗COPD呼吸衰竭合并肺部真菌感染患者可调节血气指标、抑制机体炎性反应,提高临床疗效。OBJECTIVE To observe the effect of ambroxol combined with naloxone on treatment of chronic obstructive pulmonary disease(COPD) respiratory failure patients complicated with pulmonary fungal infection.METHODS A total of 102 COPD respiratory failure patients complicated with pulmonary fungal infection who were treated in Foshan Traditional Chinese Medicine Hospital from May 2020 to May 2021 were randomly chosen as the study subjects and divided into the control group and the study group by double-blind method,the control group was treated with single naloxone,and the study group was given naloxone combined with ambroxol.The arterial blood gas indexes,lung function indexes and inflammatory factors were detected for the two groups of patients after treatment for 7 days.RESULTS After the treatment,the arterial partial pressure of oxygen(PaO),arterial oxygen saturation(SaO),forced vital capacity(FVC) and forced expiratory volume in 1 second(FEV1) of the two groups of patients were elevated,the partial pressure of carbon dioxide(PaCO) and pulmonary artery systolic pressure(PASP) were reduced,and the above indexes of the study group were significantly better than those of the control group(P<0.05).The levels of soluble intercellular adhesion molecule(sICAM-1),interleukin-6(IL-6),C-reactive protein(CRP) and hepcidin(HEPC) were reduced,the cholinesterase(CHE) level was elevated,and the above indexes of the study group were significantly better than those of the control group(P<0.05).The total effective rate of clinical curative effect was 98.03% in the study group,86.27% in the control group,and there was significant difference between the two groups(P<0.05).CONCLUSION Ambroxol combined with naloxone can regulate blood gas indexes,inhibit inflammatory response and improve clinical curative effect on the COPD respiratory failure patients complicated with pulmonary fungal infection.

关 键 词：氨溴索 纳洛酮 慢性阻塞性肺疾病 呼吸衰竭 肺部真菌感染 

分 类 号：R563.1[医药卫生—呼吸系统]