阴道衣原体和淋球菌感染对局部免疫及炎症因子表达的影响  

Influence of Vaginal Chlamydia and Gonococcal Infection on the Expression of Local Immune and Inflammatory Factors

作　　者：徐春红 吴英 薄扬 XU Chunhong;WU Ying;BO Yang(Shangrao Maternal and Child Health Hospital,Jiangxi Province,Shangrao 334000,China)

机构地区：[1]江西省上饶市妇幼保健院,江西上饶334000

出　　处：《中国医学创新》2022年第33期99-102,共4页Medical Innovation of China

基　　金：江西省青年科学基金项目(20171ACB21067);江西省上饶市科技计划项目(20194CKJ15)。

摘　　要：目的:探究及观察阴道衣原体和淋球菌感染对局部免疫及炎症因子表达的影响。方法:选取2020年1月-2022年5月上饶市妇幼保健院收治的40例阴道衣原体与淋球菌混合感染患者为A组,40例阴道衣原体感染患者为B组,同时期的40例淋球菌感染患者为C组,40名体检示无感染的健康者为D组。检测及比较四组的局部免疫指标[阴道灌洗液防御素-5(HD-5)、β-防御素-1(HBD-1)及β-防御素-2(HBD-2)和细胞免疫指标(CD3^(+)、CD4^(+)及CD4/CD8)]及炎症因子[阴道灌洗液白细胞介素-4(IL-4)、白细胞介素-8(IL-8)和肿瘤坏死因子-α(TNF-α)]。结果:A组、B组及C组阴道灌洗液防御素及炎症因子均高于D组,阴道灌洗液细胞免疫指标均低于D组,A组阴道灌洗液防御素及炎症因子均高于B组和C组,阴道灌洗液细胞免疫指标均低于B组和C组,差异均有统计学意义(P<0.05)。B组和C组的阴道灌洗液防御素、细胞免疫指标及炎症因子比较,差异均无统计学意义(P>0.05)。结论:阴道衣原体和淋球菌感染可导致阴道局部免疫失衡及炎症因子的高表达,而混合感染进一步加重其失衡的状态,因此上述指标在阴道衣原体和淋球菌感染的诊治与防控中的检测价值较高。Objective:To investigate and observe the influence of vaginal chlamydia and gonococcal infection on the expression of local immune and inflammatory factors.Method:A total of 40 patients with vaginal mixed infection of chlamydia and gonococcal in Shangrao Maternal and Child Health Hospital from January 2020 to May 2022 were chosen as the group A,40 patients with vaginal Chlamydia infection were chosen as the group B,40 patients with vaginal Gonococcal infection were chosen as the group C,40 healthy women without infection were chosen as the group D.The local immune indexes[vaginal lavage fluid defencin-5(HD-5),β-defencin-1(HBD-1),β-defencin-2(HBD-2)and cellular immune indexes(CD3^(+),CD4^(+)and CD4/CD8)]and inflammatory factors[interleukin-4(IL-4),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)in vaginal lavage fluid]were detected and compared among the four groups.Result:The vaginal lavage fluid defensins and inflammatory factors of the group A,group B and group C were higher than those of the group D,the vaginal lavage fluid cellular immune indexes were lower than those of the group D,the vaginal lavage fluid defensins and inflammatory factors of the group A were higher than those of the group B and group C,the vaginal lavage fluid cellular immune indexes of the group A were lower than those of the group B and group C,the differences were statistically significant(P<0.05).There were no significant differences in the vaginal lavage fluid defensins,cellular immune indexes and inflammatory factors between group B and group C(P>0.05).Conclusion:The vaginal chlamydia and gonococcal infection can lead to vaginal local immune imbalance and high expression of inflammatory factors,and the mixed infection further aggravates their imbalance,so their detection value for the diagnosis,treatment and prevention of vaginal chlamydia and gonococcal infection are higher.

关 键 词：阴道感染 衣原体 淋球菌 局部免疫 炎症因子 

分 类 号：R711[医药卫生—妇产科学]