餐前负荷联合阿托伐他汀对2型糖尿病患者颈动脉斑块的影响  

Effect of Premeal Load Combined with Atorvastatin on Carotid Plaque in Patients with Type 2 Diabetes Mellitus

作　　者：赖阿娜 糜华 曾维伟 杨昭[1] 杨洲[1] 冯骞 AI A’na;MI Hua;ZENG Weiwei;YANG Zhao;YANG Zhou;FENG Qian(Pingxiang People’s Hospital,Jiangxi Province,Pingxiang 337000,China;不详)

机构地区：[1]江西省萍乡市人民医院,江西萍乡337000

出　　处：《中国医学创新》2022年第31期5-9,共5页Medical Innovation of China

基　　金：江西省卫生健康委普通科技计划项目(202212206)。

摘　　要：目的:研究餐前负荷联合阿托伐他汀对2型糖尿病(T2DM)患者颈动脉斑块的影响。方法:采取前瞻性研究,以萍乡市人民医院2021年1-9月诊断并治疗的T2DM合并颈动脉粥样硬化斑块患者60例作为研究对象,采用信封法随机分为观察组及对照组,各30例。观察组患者采取餐前负荷联合阿托伐他汀治疗,对照组采取阿托伐他汀治疗。比较两组患者的血糖、血脂、超声指标、治疗效果及不良反应之间的差异。结果:治疗后,观察组患者的总有效率(90.00%)显著高于对照组(56.67%),差异有统计学意义(P<0.05);两组患者的空腹血糖(fasting blood glucose,FBG)、糖化血红蛋白(hemoglobin A1c,HbA1c)、24 h平均血糖(MBG)、24 h血糖标准差(SDBG)均低于治疗前,且观察组患者的FBG、HbA1c及24 h MBG、24 h SDBG均低于对照组,差异均有统计学意义(P<0.05);两组患者血脂各项指标均优于治疗前,且观察组患者的血脂各项指标均优于对照组,差异均有统计学意义(P<0.05);两组患者颈动脉内膜中层厚度(IMT)、血管阻力指数(RI)、收缩期峰值血流速度(PSV)、舒张末期血流速度(EDV)均优于治疗前,且观察组患者的IMT、PSV均显著低于对照组(P<0.05),EDV高于对照组(P<0.05),两组治疗后RI比较,差异无统计学意义(P>0.05);两组患者治疗期间的发热、腹泻、皮疹发生率比较,差异均无统计学意义(P>0.05)。结论:2型糖尿病患者采取餐前负荷联合阿托伐他汀治疗,糖脂代谢显著改善,颈动脉斑块显著缓解,建议临床推广。Objective:To study the effect of premeal load combined with Atorvastatin on carotid plaque in patients with type 2 diabetes mellitus (T2DM).Method:This study was a prospective study,a total of 60 patients with T2DM complicated with carotid atherosclerotic plaques diagnosed and treated in Pingxiang People’s Hospital from January to September 2021 were selected as the research objects and randomly divided into observation group and control group,30 cases in each group.The observation group was treated with premeal load combined with Atorvastatin,while the control group was treated with Atorvastatin.The differences in blood glucose,blood lipids,ultrasound indexes,treatment effects and adverse reactions were compared between the two groups.Result:After treatment,the total effective rate of the observation group was 90.00% higher than 56.67% of control group,the difference was statistically significant (P<0.05);fasting blood glucose (FBG),hemoglobin A1c (HbA1c),24-hour mean blood glucose (MBG) and 24-hour standard deviation of blood glucose (SDBG) in the two groups were lower than those before treatment,and the FBG,HbA1c and 24 h MBG,24 h SDBG of the observation group were lower than those of control group,the differences were statistically significant (P<0.05);the blood lipid indexes of the two groups were better than those before treatment,and the blood lipid indexes of the observation group were better than those of the control group,the differences were statistically significant (P<0.05);the carotid intima-media thickness (IMT),vascular resistance index (RI),peak systolic blood flow velocity (PSV) and end-diastolic blood flow velocity (EDV) in the two groups of patients were better than those before treatment,and the IMT and PSV of patients in the observation group were significantly lower than those of control group (P<0.05),and the EDV was higher than that of control group (P<0.05),there was no significant difference in RI between the two groups after treatment (P>0.05).There were no significant differences in

关 键 词：2型糖尿病 餐前负荷 阿托伐他汀 糖脂代谢 颈动脉斑块 

分 类 号：R587.1[医药卫生—内分泌]