血浆sCD36水平对冠状动脉粥样硬化斑块稳定性的影响  

The effects of plasma sCD36 levels on the stability of coronary atherosclerotic plaques

作　　者：吴小平[1] 方红薇[1] 张秋实[1] 刘怀莉[1] 马静[1] Wu Xiaoping

机构地区：[1]杭州市第三人民医院,310009

出　　处：《浙江临床医学》2022年第9期1294-1296,共3页Zhejiang Clinical Medical Journal

基　　金：浙江省医药卫生科技计划面上项目(2020KY724)。

摘　　要：目的探讨血浆sCD36水平对冠状动脉粥样硬化斑块稳定性的影响.方法选择2018年1月至2021年1月冠状动脉粥样硬化性心脏病患者127例,分为A、B、C 3组,通过酶联免疫吸附测定法检测血浆sCD36浓度,通过血管内超声检查冠状动脉粥样硬化斑块的组织特征,比较各组基本特征及动脉粥样硬化斑块特征,分析富含脂质斑块的独立预测因素.结果体重指数、高血压、血脂异常、ACS患病率、血浆sCD36水平及硝酸甘油使用各组间差异有统计学意义(P<0.05).C组总脂质体积增高,而纤维体积和致密纤维体积则降低(P<0.05).sCD36水平与脂质体积显著相关(P<0.001),而与纤维体积呈负相关(P<0.001).sCD36水平是独立与富含脂质斑块存在显著相关的因素(P<0.001).结论血浆sCD36在临床症状严重的患者中表达升高,并与斑块脂质体积显著相关.Obejetive To invstigate the efecet of plasma sCD36 leves on the stability of coronary atherosclerotic plaques.Methods A total of 127 patients with coronary heart disease admitted to Hangzhou Third People's Hospital from January 2018 to January 2021 were selected and divided into three groups:A.B and C.The sCD36 in plasma samples was detected by enzyme-linked immunosorbent asasy(ELISA).Concentrations were detected,and the tissue characteristics of coronary atherosclerotic plaques were examined by intravascular ultrasound to compare basic characteristics,atherosclerotic plaque characteristics,and independent predictors of lipid-rich plaques.Results Body mass index,hypertension,dyslipidemia,prevalence of ACS,plasma sCD36 level and nitroglycerin use were significandly dfferent among groups(P<0.05).The total lipid volume fraction was sgnifcandly higher in group C,while the fiber volume and dense fiber volume were significantly lower(P<0.05).sCD36 levels were signifcanly correlated with lipid volume percentage(P<0.001)and negatively crrelated with fiber volume percentag(P<0.001).sCD36 levels were independently and sgnifcanl'y asociated with the presence of lipid-rich plaques(P<0001).Conclusion Plasma sCD36 expression is clevated in patients with severe clinical symptons,and is sgificandly correlated with the percentage of plaque lipid volume.

关 键 词：sCD36 动脉粥样硬化 斑块稳定性 心脏超声 免疫组织化学 

分 类 号：R541.4[医药卫生—心血管疾病]