血清总钙水平与系统性红斑狼疮活动度的相关性研究  

Study on the Relationship between Serum Total Calcium Level and Activity of Systemic Lupus Erythematosus

作　　者：寸杏珠 傅萍 CUN Xingzhu;FU Ping(Rheumatology and Immunology Department,The Second Affiliated Hospital of Kunming Medical University,Yunnan 650101,China)

机构地区：[1]昆明医科大学第二附属医院风湿免疫科,650001

出　　处：《医学研究杂志》2022年第11期57-61,共5页Journal of Medical Research

基　　金：国家自然科学基金资助项目(81860287)。

摘　　要：目的探讨血清总钙水平与系统性红斑狼疮(systemic lupus erythematosus,SLE)活动度的相关性。方法回顾性收集2016年1月~2021年12月于昆明医科大学第二附属医院首次诊断系统性红斑狼疮并且入院前未经规范药物治疗的102例SLE患者,用SLE疾病活动度指数(systemic lupus erythematosus disease activity index,SLEDAI)评分将SLE患者分为低疾病活动度组(SLEDAI<10分)和高疾病活动度组(SLEDAI≥10分),对照组为随机选取的健康体检者57例,对3组患者临床资料、血清总钙水平进行对比分析;将SLE患者血清总钙水平与SLEDAI评分进行相关性分析。结果3组患者在年龄、性别方面比较,差异有统计学意义;高疾病活动度组血清总钙水平明显低于低疾病活动度组及对照组,低疾病活动度组血清总钙水平明显低于对照组;按照年龄和性别进行分层分析,SLE病例组的血清总钙水平明显低于对照组;SLE病例组的血清总钙水平与SLEDAI评分呈负相关(P<0.05)。结论血清总钙水平与SLE疾病活动度具有相关性,在临床工作中监测SLE患者血清总钙水平变化可帮助判断狼疮患者疾病活动度。Objective To explore the relationship between serum total calcium level and activity of systemic lupus erythematosus(systemic lupus erythematosus,SLE).Methods From January 2016 to December 2021,102 SLE patients who were first diagnosed with systemic lupus erythematosus in the Second Affiliated Hospital of Kunming Medical University and were not treated with standard drugs were retrospectively collected.The SLE patients were divided into low disease activity group(SLEDAI<10)and high disease activity group(SLEDAI≥10)by SLE disease activity index(systemic lupus erythematosus disease activity index,SLEDAI)score,and 57healthy subjects were randomly selected as the control group.The clinical data and serum total calcium levels of the three groups were compared and analyzed.The correlation between serum total calcium level and SLEDAI score in patients with SLE was analyzed.Results There were differences in age and sex among the three groups:the serum total calcium level in the high disease activity group was significantly lower than that in the low disease activity group and the control group,and the serum total calcium level in the low disease activity group was significantly lower than that in the control group.Stratified analysis according to age and sex,the serum calcium level in the SLE group was significantly lower than that in the control group,and there was a negative correlation between the serum total calcium level and the SLEDAI score in the SLE group(P<0.05).Conclusion There is a correlation between serum total calcium level and SLE disease activity.Monitoring the changes of serum total calcium level in patients with SLE can help to judge the disease activity in lupus patients.

关 键 词：红斑狼疮 钙 疾病 

分 类 号：R593.24[医药卫生—内科学]