异种心脏移植基因修饰策略及围手术期管理研究进展  

The research progress in gene modification strategies and perioperative management of cardiac xenotransplantation

作　　者：任明仕 王嵘 王明岩 张丽月 成楠 吴远斌 Ren Mingshi;Wang Rong;Wang Mingyan;Zhang Liyue;Cheng Nan;Wu Yuanbi(Dwision of Cardiac Surgery,Department of Cardiology,the Sixth Medical Center,Chinese PIA General Hospital,Beijing 100039,China;Medical School of Chinese PLA.,Beijing 100039,China)

机构地区：[1]中国人民解放军总医院第六医学中心心血管外科,北京100039 [2]解放军医学院,北京100039

出　　处：《中华移植杂志（电子版）》2022年第3期183-189,共7页Chinese Journal of Transplantation(Electronic Edition)

基　　金：国家重点专项研发计划(2019YFA0110704)。

摘　　要：异种心脏移植(CXTx)为解决终末期心衰患者心脏移植供器官短缺提供了广阔的发展前景,是缓解供心短缺的可行策略。人源化基因修饰技术的进步为CXTx临床应用翻开了新篇章。CXTx动物模型的建立为解决异种排斥反应探索出一条可行的技术路线,显著延长移植器官存活时间。本文综述近年来异位和原位CXTx的研究进展,并从多项前瞻性临床前研究的数据中筛选出部分相关数据进行分析,探讨CXTx动物模型的构建策略及可能优化的治疗方案,以期为临床提供借鉴。Cardiac xenotransplantation(CXTx)offers a promising development to address the shortage of donor organs for patients with end-stage heart failure and is a viable strategy to alleviate the shortage of donor hearts.The progress of humanized gene modification technology has opened a new chapter for the clinical application of xenotransplantation.The establishment of animal model of cardiac xenotransplantation has explored a feasible technical route to solve the xenorejection reaction and significantly extended the survival time of transplanted organs.This review will discuss the recent research results of ectopic and orthotopic cardiac xenotransplantation,and some relevant data were selected from several prospective preclinical studies for analysis to explore the construction strategy of heterotopic heart transplantation model and the possible optimal treatment plan,to provide reference for clinic.

关 键 词：器官移植 异种移植 抗体介导排斥反应 α-1 3-半乳糖基转移酶 基因编辑 补体调节蛋白 

分 类 号：R654.2[医药卫生—外科学]