1990-2019年中国0~14岁儿童白血病疾病负担分析  

Analysis on the burden of leukemia disease in children aged 0-14 years in China

作　　者：雷蕾 陆翘楚 杜一骏 冯园惠 李永丰 饶璐 康敏[3] LEI Lei;LU Qiao-chu;DU Yi-jun;FENG Yuan-hui;LI Yong-feng;RAO Lu;KANG Min(Guangdong Medical Academic Exchange Center,Guangzhou Guangdong 510180,China;Weiji Medicine Development Foundation of Guangdong Province,Guangzhou Guangdong 510623,China;Infectious Disease Prevention and Control Institute of Guangdong CDC,Guangzhou Guangdong 511430,China)

机构地区：[1]广东省医学学术交流中心,广东广州510180 [2]广东省卫济医学发展基金会,广东广州510623 [3]广东省疾病预防控制中心传染病预防控制所,广东广州511430

出　　处：《卫生软科学》2022年第12期79-84,共6页Soft Science of Health

基　　金：广东省医学科学技术研究基金(A2022526)。

摘　　要：[目的]分析1990-2019年中国0~14岁儿童白血病疾病负担各指标的变化趋势,了解中国儿童白血病疾病负担现状,为儿童白血病的防控提供参考。[方法]根据全球疾病负担研究2019年数据库(GBD 2019),按照不同性别、年龄、疾病类型分析儿童白血病死亡率、伤残调整寿命年(DALY)率、损失寿命年(YLL)率和伤残损失寿命年(YLD)率,评价1990-2019年中国0~14岁儿童白血病疾病负担的变化情况。[结果]1990-2019年,我国0~14岁儿童白血病死亡率由1990年的6.9/10万降低至2019年的2.14/10万;DALY率由595.75/10万降低至184.65/10万,YLD率由14.92/10万降低至7.60/10万,YLL率由580.83/10万降低至177.04/10万。2019年,男性患儿死亡率、DALY率、YLD率、YLL率分别为2.39/10万、205.56/10万、7.93/10万、197.63/10万,均高于女性患儿(1.84/10万、160.07/10万、7.22/10万、152.84/10万)。0~4岁儿童死亡率、DALY率、YLD率、YLL率分别为2.72/10万、247.93/10万、11.18/10万、236.75/10万,均高于其他年龄组患儿。0~14岁儿童急性淋巴细胞白血病(ALL)的YLD率由0.56/10万升高至2.36/10万。[结论]我国儿童白血病防控工作取得一定成效,但疾病负担仍然较高。应加强男性、0~4岁和急性淋巴细胞白血病患儿的防控工作,关注接受治疗延长生命的患儿生存状态,降低儿童白血病疾病负担。Objective This study aims to analyze variation trends of leukemia disease burden in children aged 0-14 years in China from 1990 to 2019,and understand current situation of disease burden of pediatric leukemia in China, so as to provide reference for the prevention and control of leukemia disease in children. Methods According to the Global Burden of Diseases Study 2019 Database(GBD 2019). The mortality rate, disability-adjusted life years(DALY)rate, life years lost(YLL)rate and life years lost for disability(YLD)rate of children with leukemia were analyzed by different gender, ages and disease types to evaluate the burden of leukemia disease in children aged 0-14 years in China from 1990 to 2019. Results From 1990 to 2019,the mortality rate of leukemia disease in children aged 0-14 years in China decreased from 6.9/100,000 in 1990 to 2.14/100,000 in 2019. The DALY rate decreased from 595.75/100,000 to 184.65/100,000,the YLD rate decreased from 14.92/100,000 to 7.60/100,000,and the YLL rate decreased from 580.83/100,000 to 177.04/100,000. In 2019,the mortality rate, DALY rate, YLD rate, and YLL rate of boys was 2.39/100,000,2.0556/100,000,7.93/100,000,and 1.9763/100,000,respectively, which were higher than those of girls(1.84/100,000,160.07/100,000,7.22/100,000,152.84/100,000). The mortality rate, DALY rate, YLD rate, and YLL rate of children aged 0-4 were 2.72/100,000,247.93/100,000,11.18/100,000,and 236.75/100,000,which were higher than those of other age groups. In acute lymphoblastic leukemia(ALL)in children aged 0-14 years, the YLD rate increased from 0.56/100,000 to 2.36/100,000. Conclusions Although the prevention and control of childhood leukemia has achieved some success, the disease burden is still heavy. We should strengthen the prevention and control work for boy, 0-4 years old children with acute lymphoblastic leukemia, pay more attention to the survival status of children receiving life-prolonging treatments, so as to reduce the burden of leukemia disease in children.

关 键 词：疾病负担 白血病 儿童 

分 类 号：R195.3[医药卫生—卫生统计学] R181.2[医药卫生—卫生事业管理]