球囊损伤动物模型建立与运用的研究进展  

Progressing on methods of creating balloon injury animal model and its application

作　　者：周思静 罗诗雯 潘永豪 庹勤慧 杨冬梅 ZHOU Sijing;LUO Shiwen;PAN Yonghao;TUO Qinhui;YANG Dongmei(School of Medicine,Hunan University of Traditional Chinese Medicine,Changsha,Hunan 410208,China;College of Integrated Traditional Chinese and Western Medicine,Hunan University of Traditional Chinese Medicine,Hunan 410208,China)

机构地区：[1]湖南中医药大学医学院,湖南省长沙市410208 [2]湖南中医药大学中西医结合学院,湖南省长沙市410208

出　　处：《中国动脉硬化杂志》2022年第12期1098-1104,共7页Chinese Journal of Arteriosclerosis

基　　金：湖南省自然科学基金项目(2022JJ40314);湖南省重点研发计划项目(2022SK2011);湖南省教育厅重点项目(20A379);湖南省教育厅一般项目(19C1421);湖南中医药大学校级项目(2020XJJJ010);湖南中医药大学大学生创新创业训练计划项目(2021127)。

摘　　要：心血管疾病是造成人类死亡的首要原因。其中,血管狭窄疾病在心血管疾病中占比高,严重危害着人们身心健康。支架介入治疗是目前治疗血管狭窄最常用的方法,但冠状动脉、颈动脉和其他外周动脉经皮腔内血管成形术后再狭窄比例非常高,严重影响了介入治疗患者的预后。稳定的动物模型能够为研究解决经皮介入治疗术后再狭窄提供工具。因此,文章整理了球囊损伤动物模型的建立方法及运用研究进展,以期为防治心血管疾病的研究提供依据。Cardiovascular diseases are the leading cause of human death.Among them,vascular stenosis diseases account for a high proportion of cardiovascular diseases,which seriously endanger people s physical and mental health.Stent intervention is currently the most commonly used method for the treatment of vascular stenosis,but the proportion of restenosis after percutaneous intervention of coronary,carotid and peripheral arteries is very high,which seriously affects the prognosis of interventional patients.Therefore,a stable animal model can provide a tool for research and resolution of restenosis after percutaneous intervention.This article summarizes the method of creating ballon injury animal model and its application,in order to provide basis for the prevention and treatment of cardiovascular diseases.

关 键 词：球囊损伤 动物模型 心血管疾病 经皮腔内血管成形术 血管再狭窄 

分 类 号：R5[医药卫生—内科学]