血清α1-MG和NGAL在狼疮肾炎早期诊断中的临床价值  

Clinical value of serumα1-MG and NGAL in the early diagnosis of lupus nephritis

作　　者：马珍[1] 杨朝美 MA Zhen;YANG Chaomei(Department of Infection and Disease Control;Department of Clinical Laboratory,The Fourth People′s Hospital of Chongqing/Chongqing Emergency Medical Center,Chongqing 400014,China)

机构地区：[1]重庆市第四人民医院/重庆市急救医疗中心感染与疾病预防控制科,重庆400014 [2]重庆市第四人民医院/重庆市急救医疗中心检验科,重庆400014

出　　处：《国际检验医学杂志》2022年第23期2933-2936,共4页International Journal of Laboratory Medicine

摘　　要：目的探讨血清α_(1)-微球蛋白(α_(1)-MG)和中性粒细胞明胶酶相关载脂蛋白(NGAL)在狼疮肾炎(LN)早期诊断中的临床价值。方法选取2019年3月至2021年4月该院收治的LN患者102例作为LN组,另选择同期健康体检者114例作为对照组。比较两组血清α_(1)-MG、NGAL、尿素(Urea)、肌酐(Cr)、尿酸、胱抑素C(Cys C)水平;分析LN发生的影响因素;绘制受试者工作特征(ROC)曲线评估血清α_(1)-MG、NGAL对LN的诊断价值。结果LN组血清α_(1)-MG、NGAL、Urea、Cr、Cys C水平与对照组比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,血清α_(1)-MG、NGAL水平升高是LN发生的独立危险因素(P<0.05)。ROC曲线分析结果显示,α_(1)-MG诊断LN的曲线下面积(AUC)为0.723,灵敏度为64.7%,特异度为93.0%;NGAL诊断LN的AUC为0.814,灵敏度为73.5%,特异度为86.0%,两项联合检测的AUC为0.842,灵敏度为73.5%,特异度为86.3%。结论血清NGAL和α_(1)-MG水平升高是LN发生的独立危险因素,且二者对LN的诊断价值较高,可作为诊断LN的有效生物标志物。Objective To investigate the clinical value of serumα_(1)-microglobulin(α_(1)-MG)and neutrophil gelatinase-associated lipocalin(NGAL)in the early diagnosis of lupus nephritis(LN).Methods A total of 102 patients with LN admitted to the hospital from March 2019 to April 2021 were selected as the LN group,and 114 healthy people underwent physical examination in the same period were selected as the control group.The serum levels of α_(1)-MG,NGAL,Urea,creatinine(Cr),uric acid and cystatin C(Cys C)were compared between the two groups.The influencing factors for the occurrence of LN were analyzed.The receiver operating characteristic(ROC)curve was drawn to evaluate the diagnostic value of serum α_(1)-MG and NGAL for LN.Results The levels of serum α_(1)-MG,NGAL,Urea,Cr and Cys C in the LN group were significantly different from those in the control group(P<0.05).Multivariate Logistic regression analysis showed that increased serum α_(1)-MG and NGAL levels were independent risk factors for the occurrence of LN(P<0.05).ROC curve analysis showed that the area under curve(AUC)of α_(1)-MG in the diagnosis of LN was 0.723,the sensitivity was 64.7%,and the specificity was 93.0%.The AUC of NGAL in the diagnosis of LN was 0.814,the sensitivity was 73.5%,and the specificity was 86.0%.The AUC of the two combined detection was 0.842,the sensitivity was 73.5%,and the specificity was 86.3%.Conclusion Elevated serum levels of NGAL and α_(1)-MG are risk factors for the occurrence of LN,and they have high diagnostic value for LN and can be used as effective biomarkers for the diagnosis of LN.

关 键 词：狼疮肾炎 Α1-微球蛋白 中性粒细胞明胶酶相关载脂蛋白 系统性红斑狼疮 

分 类 号：R593.242[医药卫生—内科学]