小剂量新活素联合托拉塞米静脉注射治疗急性左心衰的效果观察  

Effect of Low-dose Lyophilized Recombinant Human Brain Natriuretic Peptide Combined with Torasemide Intravenous Injection in the Treatment of Acute Left Heart Failure

作　　者：舒海燕[1] SHU Haiyan(Department of Internal Medicine,Shitai County People’s Hospital,Chizhou 245100,China)

机构地区：[1]石台县人民医院内一科,安徽池州245100

出　　处：《湖北民族大学学报（医学版）》2022年第4期32-35,共4页Journal of Hubei Minzu University(Medical Edition)

摘　　要：目的对小剂量新活素(冻干重组人脑利钠肽)联合托拉塞米静脉注射治疗急性左心衰竭(ALHF)的效果进行观察。方法选取石台县人民医院2018年12月-2021年12月收治的50例ALHF患者为研究对象,采用随机数表法将患者分为对照组(传统治疗联合托拉塞米,n=25)和试验组(小剂量新活素联合托拉塞米静脉注射联合治疗,n=25),比较两组患者临床疗效、心功能指标、肾功能指标、利尿剂用量及尿量变化以及不良反应情况。结果试验组治疗有效率显著高于对照组(χ2=4.500,P<0.05);治疗后试验组心指数(CI)显著高于对照组,血浆N端脑钠素前体(NtproBNP)显著低于对照组(P<0.05),治疗后试验组患者肾功能指标均有改善(P<0.05),对照组肾功能指标较治疗前未显著改善(P>0.05),试验组血肌酐(Scr)、血尿素氮(BUN)水平显著低于对照组(P<0.05),治疗后两组24 h尿量均有增加,试验组患者24 h尿量显著多于对照组,利尿剂用量少于对照组(P<0.05);治疗期间两组患者不良反应发生率分别为12.00和8.00%,差异无统计学意义(P>0.05)。结论小剂量新活素联合托拉塞米静脉治疗可显著改善患者临床症状,还能有效改善患者心功能与肾功能。Objective To observe the effect of low-dose lyophilized recombinant human brain natriuretic peptide combined with torasemide intravenous injection in the treatment of acute left heart failure(ALHF).Methods 50 patients with ALHF admitted to the hospital from December 2018 to December 2021 were selected as the research subjects.According to random number table method,the patients were divided into control group(conventional treatment combined with torsemide,n=25)and experimental group(low-dose lyophilized recombinant human brain natriuretic peptide combined with torsemide intravenous injection,n=25).Clinical effects,changes in cardiac function indicators,renal function indicators,dosage of diuretics and urine volume,and adverse reactions were compared between the two groups.Results The treatment response rate of experimental group was 92.00%(23/25),and significantly higher than that of the control group[68.00%(17/25)](P<0.05).There was no statistically significant difference in cardiac function indicators between the two groups before treatment(P>0.05).After treatment,cardiac function indicators in the two groups were improved.Cardiac index(CI)of the experimental group was significantly higher than that of the control group,while N-terminal pro-brain natriuretic peptide(NTproBNP)level was significantly lower than that of the control group(P<0.05).There was no statistically significant difference in renal function indicators between the two groups before treatment(P>0.05).After treatment,renal function indicators in the experimental group were improved(P<0.05),but there were no significant changes in the control group(P>0.05).The levels of serum creatinine(Scr)and blood urea nitrogen(BUN)in experimental group were significantly lower than those in the control group(P<0.05).There was no statistically significant difference in 24 h urine volume between the two groups before treatment(P>0.05).After treatment,24 h urine volume of the two groups was increased.Meanwhile,24 h urine volume of the experimental group was sign

关 键 词：急性左心衰竭 冻干重组人脑利钠肽 托拉塞米 

分 类 号：R541.6[医药卫生—心血管疾病]