厦门地区3 805例女性HPV感染情况分析  

Analysis of HPV infection in 3805 women in Xiamen area

作　　者：陈海明[1] 陈晓铭 王前明[1] 逯晓辉[1] CHEN Haiming;CHEN Xiaoming;WANG Qianming;LU Xiaohui(Department of Clinical Laboratory,the First Affiliated Hospital of Xiamen University/Xiamen Key Laboratory of Genetic Testing,Xiamen,Fujian 361001,China;Department of Laboratory Medicine,School of Pharmacy and Medical Technology,Putian,Fujian 351100,China)

机构地区：[1]厦门大学附属第一医院检验科/厦门市基因检测重点实验室,福建厦门361001 [2]药学与医学技术学院医学检验系,福建莆田351100

出　　处：《检验医学与临床》2022年第23期3202-3205,共4页Laboratory Medicine and Clinic

基　　金：福建省自然科学基金项目(2019J01568)。

摘　　要：目的分析厦门地区女性人乳头瘤病毒(HPV)感染情况及其亚型分布特征,为区域相关疾病的诊疗和预防提供基础理论依据。方法选取2017年1月至2019年12月于厦门大学附属第一医院就诊及体检部健康查体的3805例女性患者作为研究对象,回顾性分析其HPV微流控芯片技术检测结果,分析该地区女性HPV感染情况及各亚型分布特点。结果厦门地区3805例女性HPV检出率为26.83%(1021/3805),其中单一感染构成比为71.99%(735/1021),多重感染构成比为28.01%(286/1021);24种HPV亚型中检出率最高的是HPV52型(6.57%),其次是HPV16型(3.63%)、HPV58型(3.00%)、HPV51型(2.60%)、HPV39型(1.92%);≤20岁年龄段的女性HPV检出率最高(38.46%),检出率最低的是>40~50岁的女性(21.81%);单一感染检出率最高的年龄段是>50~60岁(25.99%),≤20岁的女性单一感染检出率最低(12.82%)而多重感染检出率却最高(25.64%),>30~40岁女性多重感染检出率最低(5.77%)。结论厦门地区女性HPV感染特征以单一感染为主,存在年龄分布差异,24种亚型中检出率最高的前5个型别依次为HPV52型、HPV16型,HPV58型、HPV51型、HPV39型。应重视该地区不同年龄段女性的HPV感染筛查,并根据地区感染特点进行预防接种。Objective To analyze the distribution characteristics of human papillomavirus(HPV)infection and its subtypes among women in Xiamen,so as to provide basic theoretical basis for the diagnosis,treatment and prevention of related diseases.Methods Female patients(3805 cases)who were admitted to the First Affiliated Hospital of Xiamen University and underwent physical examination from January 2017 to December 2019 were selected as the research objects.The results of HPV microfluidic chip technology were retrospectively analyzed,and the distribution characteristics of female HPV infection and subtypes in this area were statistically analyzed.Results The detection rate of HPV in 3805 women in Xiamen was 26.83%(1021/3805),among which the proportion of single infection was 71.99%(735/1021),while the proportion of multiple infection was 28.01%(286/1021).Among the 24 HPV subtypes,the highest detection rate was HPV52(6.57%),followed by HPV16(3.63%),HPV58(3.00%),HPV51(2.60%)and HPV39(1.92%).The detection rate of HPV was the highest(38.46%)in women aged less than or equal to 20 years old,and the lowest in women aged more than 40 to 50 years old(21.81%).The age group with the highest single detection rate was more than 50 to 60 years old(25.99%).The single detection rate was the lowest among women aged less than or equal to 20 years old(12.82%),while the multiple detection rate was the highest(25.64%).Women aged more than 30 to 40 years old had the lowest multiple detection rate(5.77%).Conclusion The main characteristic of HPV infection in women in Xiamen is single infection,and there were differences in age distribution.The first five types with the highest detection rates among the 24 subtypes are HPV52,HPV16,HPV58,HPV51 and HPV39.Attention should be paid to the screening of HPV infection among women of different ages in this area,and vaccination should be carried out according to the characteristics of infection in the area.

关 键 词：人乳头瘤病毒 亚型 微流控芯片技术 女性 厦门 

分 类 号：R446.5[医药卫生—诊断学] R737.33[医药卫生—临床医学]