p300/CBP在肾脏纤维化的作用和机制  

The role and mechanism of p300/CBP in renal fibrosis

作　　者：王艳哲 吴明(综述) 叶朝阳(审校) WANG Yanzhe;WU Ming;YE Chaoyang(Department of Nephrology,Shuguang Hospital Affiliated to Shanghai Traditional Chinese Medicine University,TCM institute of kidney disease,Shanghai University of Traditional Chinese Medicine,Key Laboratory of Liver and Kidney Diseases,Ministry of Education,Shanghai Key Laboratory of Traditional Chinese Clinical Medicine,Shanghai University of Traditional Chinese Clinical Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院肾病科,上海中医药大学中医肾病研究所,肝肾疾病病证教育部重点实验室(上海中医药大学),上海市中医临床重点实验室,上海201203

出　　处：《肾脏病与透析肾移植杂志》2022年第5期461-464,500,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：国家自然科学基金项目(82170747)。

摘　　要：肾脏纤维化是各种病因引起的慢性肾脏病的主要病理改变,常进展至终末期肾病。组蛋白乙酰转移酶(HATs)介导的表观遗传调控在肾脏纤维化的发生发展中发挥重要作用。由高度同源的腺病毒E1A相关的300 kD蛋白(p300)和环磷酸腺苷反应元件结合蛋白(CREB)的结合蛋白(CBP)组成的p300/CBP家族是HATs家族主要成员之一。本文总结了目前关于p300/CBP的结构、功能及其在肾脏纤维化中的作用和机制。旨在对肾脏纤维化的防治提供新的靶点和思路。Renal fibrosis is the main pathological change of chronic kidney disease with various causes.It has been found that histone acetyltransferases(HATs)mediated epigenetic modification was tightly associated with the occurrence and development of renal fibrosis.The p300/CBP family consisting of the highly homologous adenovirus E1 A-associated 300 kDa protein(p300)and cAMP responsive element binding protein(CREB)binding protein(CBP)is one of the major members of the HATs families.This paper reviewed the structure,function,and the role of p300/CBP in renal fibrosis,attempting to provide new targets and ideas for the prevention and treatment of renal fibrosis.

关 键 词：组蛋白乙酰转移酶 P300/CBP 肾脏纤维化 

分 类 号：R692[医药卫生—泌尿科学]