供体来源细胞游离DNA在肾移植中的研究  

Research on donor-derived cell-free DNA in kidney transplantation

作　　者：孙欣 张涛(综述)[1] 唐亮(审校) SUN Xin;ZHANG Tao;TANG Liang(Department of Urology,the Second Hospital of Anhui Medical University,Hefei 230032,China)

机构地区：[1]安徽医科大学第二附属医院泌尿外科,合肥230032

出　　处：《肾脏病与透析肾移植杂志》2022年第5期485-489,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：安徽省自然科学基金面上项目(2008085MH290);安徽医科大学基础与临床合作研究提升计划(2021xkjT036)。

摘　　要：肾移植是终末期肾病有效治疗手段。移植物损伤是影响移植物存活的主要因素。常用方法如监测血清肌酐、尿蛋白及移植肾活检等,存在迟滞性,不确定性及有创性。供体来源细胞游离DNA(donor-derived cellfree DNA,dd-cfDNA)是一种源于供体的碎片化、可降解DNA片段。现有研究发现,dd-cfDNA在移植肾损伤监测、移植物排斥鉴别、免疫抑制方案调整等方面发挥重要作用,是一种无创、可重复且灵敏度高的新型生物标志物。本文就近年来dd-cfDNA在肾移植的研究进展做一综述。Kidney transplantation is an effective treatment for end-stage renal disease.Allograft injury is a major influential factor of allograft survival.Commonly used surveillance methods,such as plasma creatinine,proteinuria,and kidney biopsy,were found to be hysteresis,uncertainty and invasiveness.Donor-derived cell-free DNA(dd-cfDNA)is a fragmented and degradable DNA fragment derived from transplanted organs.Sudies have shown that dd-cfDNA plays a pivotal role in the monitoring of allograft injury,discerning allograft rejection,and guiding immunosuppressant management.As a novel biomarker,dd-cfDNA is non-invasive,reproducible and highly sensitive.This article will review the recent research progress on the dd-cfDNA in kidney transplantation.

关 键 词：供体来源细胞游离DNA 肾移植 生物标志物 

分 类 号：R699.2[医药卫生—泌尿科学]