补肺强心方治疗慢性血栓栓塞性肺动脉高压疗效研究  

Clinical effect of Bufei Qiangxin recipe on chronic thromboembolic pulmonary hypertension

作　　者：姚海珍[1] 冯亮[1] 解娟[1] 张明[1] 甄利波[1] YAO Haizhen;FENG Liang;XIE Juan;ZHANG Ming;ZHEN Libo(Baoding First Central Hospital,Baoding 071000,China)

机构地区：[1]保定市第一中心医院,河北保定071000

出　　处：《陕西中医》2022年第12期1713-1716,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研项目(2018432)。

摘　　要：目的:探讨补肺强心方治疗慢性血栓栓塞性肺动脉高压(CTEPH)临床疗效及对患者血管内皮功能的影响。方法:选取86例CTEPH患者,随机分成对照组和观察组。对照组采用枸橼酸西地那非等常规治疗,观察组联合补肺强心方治疗。观察两组临床症状积分、Borg呼吸困难指数评分、6 min步行距离(6MWD)、超声心动图指标[肺动脉收缩压(PASP)、右室舒张末期内径(RVEDD)、右心室Tei指数]及血管内皮功能指标[一氧化氮(NO)、内皮素-1(ET-1)、血管内皮生长因子(VEGF)]的改善情况,并比较两组临床疗效和治疗安全性。结果:观察组治疗总有效率高于对照组(P<0.05)。观察组治疗后临床症状积分、Borg呼吸困难指数、PASP、RVEDD、右心室Tei指数、ET-1、VEGF水平低于对照组(均P<0.05)。观察组治疗后6MWD、NO水平高于对照组(均P<0.05)。两组治疗期间均未出现明显不良反应。结论:补肺强心方能够调节CTEPH患者血管内皮功能,降低患者肺动脉压,改善右心室功能状态和运动耐力,疗效较好。Objective:To explore the clinical effect of Bufei Qiangxin recipe on chronic thromboembolic pulmonary hypertension(CTEPH)and its influence on vascular endothelial function.Methods:86 patients with CTEPH were randomly divided into control group and observation group.The control group were treated with sildenafil citrate and other conventional treatments,and the observation group were treated with combined with Bufei Qiangxin recipe.The improvement of clinical symptom score,Borg dyspnea index score,6-minute walking distance(6MWD),echocardiographic indexes[pulmonary artery systolic pressure(PASP),right ventricular end diastolic diameter(RVEDD),right ventricular Tei index]and vascular endothelial function indexes[nitric oxide(NO),endothelin-1(ET-1)and vascular endothelial growth factor(VEGF)]were observed in the two groups.The clinical efficacy and safety of the two groups were compared.Results:The total effective rate of the observation group was higher than that of the control group(P<0.05).The scores of clinical symptoms,Borg dyspnea index,PASP,RVEDD,Tei index of right ventricle,ET-1 and VEGF in the observation group were lower than those in the control group(all P<0.05).The levels of 6MWD and NO in the observation group were higher than those in the control group(all P<0.05).There were no obvious adverse reactions in both groups during the treatment period.Conclusion:Bufei Qiangxin recipe can regulate the vascular endothelial function,reduce the pulmonary artery pressure,and improve the right ventricular function and exercise endurance in patients with CTEPH,which has better effect.

关 键 词：慢性血栓栓塞性肺动脉高压 补肺强心方 枸橼酸西地那非 血管内皮生长因子 内皮素 心肺功能 

分 类 号：R563[医药卫生—呼吸系统]