中国艾滋病高危人群暴露前预防用药接受意愿率的Meta分析  

Meta analysis of the willingness of pre-exposure prophylaxis among high-risk population of HIV in China

作　　者：郑宇 陈燕华 罗月 李梅 蒋林芮 周锡平 ZHENG Yu;CHEN Yanhua;LUO Yue;LI Mei;JIANG Linrui;ZHOU Xiping(The Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan,China;Nursing School of Southwest Medical University,Luzhou 646000,Sichuan)

机构地区：[1]西南医科大学附属医院,四川泸州646000 [2]西南医科大学护理学院,四川泸州646000

出　　处：《中国艾滋病性病》2022年第10期1230-1234,F0003,共6页Chinese Journal of Aids & STD

基　　金：西南医科大学校级科研项目(2020ZSQN025)。

摘　　要：目的 了解中国艾滋病高危人群暴露前预防用药(PrEP)接受意愿,为进一步推广PrEP提供依据。方法在中国知网、万方、维普、中国生物医学文献数据库(CBM)、PubMed、The Cochrane Library和Web of Science检索自建库至2021年6月30日有关中国艾滋病高危人群中有接受PrEP意愿者的比例(简称PrEP意愿率)的文献,筛选、提取、整合数据后使用Stata15.0进行Meta分析。结果 共纳入37篇研究文献,中国艾滋病高危人群PrEP意愿率为68.4%(95%CI:63.3%~73.5%),在不同特征高危人群中,MSM的PrEP意愿率最高为72.4%(95%CI:66.5%~78.3%),在研究的地区中,西南地区PrEP意愿率最高为75.2%(95%CI:63.2%~87.2%)。MSM在用药偏好上,口服类PrEP意愿率为63.1%(95%CI:55.1%~71.0%),注射针剂PrEP意愿率为63.5%(95%CI:45.3%~81.7%)。事件驱动服药型PrEP意愿率高于每日服药型(67.5%vs. 50.2%)。亚组分析显示,异质性可能来源于研究地区、个人月收入差异。结论 中国艾滋病高危人群PrEP意愿率较高,不同地区、高危人群、用药偏好上存在差异,表明在我国大规模推广PrEP具有可行性,有良好使用前景。Objective To understand the willingness of preexposure prophylaxis(PrEP) acceptance among people at high-risk of HIV in China and to provide evidence for further promotion of PrEP. Methods CNKI, Wanfang, VIP,Chinese Biomedical Literature Database(CBM), PubMed, The Cochrane Library and Web of Science were used to search the literatures on the proportion of people at high risk of HIV in China who were willing to receive PrEP(referred to as PrEP willingness rate) from the databases establishment to June 30, 2021. Meta-analysis was performed using Stata15.0after screening, extracting and integrating the data. Results A total of 37 literatures were included. The willingness rate of PrEP was 68.4%(95%CI: 63.3%~73.5%) among people at high risk of HIV in China. The highest willingness rate of PrEP was 72.4%(95%CI: 66.5%~78.3%) in MSM. Among the studied areas, the highest PrEP willingness rate was 75.2%(95%CI: 63.2%~87.2%) in southwest China. In terms of medication preference, the willingness rate of MSM was 63.1%(95%CI: 55.1%~71.0%) for oral PrEP and 63.5%(95%CI: 45.3%~81.7%) for injection PrEP. Event-driven PrEP willingness was higher in the medication-taking group than in the daily medication-taking group(67.5% vs. 50.2%).Subgroup analysis showed that heterogeneity may be due to differences in study region and monthly income.Conclusions The willingness rate of PrEP was high in people at high risk of HIV in China. There were differences in geographic regions, high risk groups and medication preferences. It indicated that it was feasible to promote PrEP widely in China and had a good prospect of use.

关 键 词：艾滋病高危人群 暴露前预防用药 接受意愿 META分析 

分 类 号：R512.91[医药卫生—内科学]