一种新型铁基含氟吡啶羧酸类配合物对BSA的响应机理研究  

The mechanism of interaction between a new ferrous complex based on fluoro-pyridine carboxylic acid and bovine serum albumin

作　　者：潘铭铭 郭佳彦 赵一鹏 王玮 赵正午 李冰[1] PAN Mingming;GUO Jiayan;ZHAO Yipeng;WANG Wei;ZHAO Zhengwu;LI Bing(College of Chemistry and Chemical Engineering of Ningxia University,Yinchuan Ningxia 750021,China)

机构地区：[1]宁夏大学化学化工学院,宁夏银川750021

出　　处：《石油化工应用》2022年第10期102-105,共4页Petrochemical Industry Application

基　　金：宁夏大学大学生创新创业训练计划国家级项目,项目编号:G202210749019。

摘　　要：以5-三氟甲基吡啶-2-甲酸(Htpc)为配体构筑了一例新型铁(Ⅱ)基二元配合物[Fe(Htpc)_(2)(H_(2)O)_(2)],利用单晶衍射、元素分析、红外光谱、热重分析等对其进行表征,确定了配合物的结构。紫外和荧光光谱表明该配合物对牛血清白蛋白(BSA)的作用为静态猝灭,配合物的结合力强于配体。热力学研究表明该配合物与BSA相互结合的主导力为氢键作用和范德华力。A novel ferrous complex[Fe(Htpc)_(2)(H_(2)O)_(2)]was constructed with 5-trifluoromethylpyridine-2-carboxylic acid(Htpc)as ligand.The structure of the complex was determined by single crystal diffraction,elemental analysis,infrared spectroscopy and thermogravimetric analysis.UV and fluorescence spectra showed that the complex had a static quenching effect on bovine serum albumin(BSA),and the binding strength of the complex was stronger than that of the ligand.Thermodynamic studies show that hydrogen bonding and Van der Waals force are the dominant forces for the interaction between the complex and BSA.

关 键 词：配合物 5-三氟甲基吡啶-2-甲酸 牛血清白蛋白 

分 类 号：O657.3[理学—分析化学]