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作 者:王江南 高杰[2] 丁戊坤 宋美玉 马苗苗 金璨 郝奕菲 李旭东 WANG Jiang-nan;GAO Jie;DING Wu-kun(Heilongjiang University of Traditional Chinese Medicine,Graduate School(Harbin 150040),China)
机构地区:[1]黑龙江中医药大学研究生院,哈尔滨150040 [2]黑龙江中医药大学附属第一医院周围血管病科,哈尔滨150040
出 处:《中国中西医结合外科杂志》2022年第6期769-774,共6页Chinese Journal of Surgery of Integrated Traditional and Western Medicine
基 金:黑龙江中医药大学“双一流”中西医结合学科优秀青年基金(HLJSYL2001);黑龙江省中医药科研项目(ZHY19-036);黑龙江中医药大学新药研究基金项目(2017XY02)。
摘 要:目的:探讨芪参通脉饮Ⅱ号方治疗气血两虚、络脉瘀阻证型糖尿病足的临床疗效。方法:选取2020年10月—2021年10月收治的气血两虚、络脉瘀阻证型糖尿病足患者80例,随机分为治疗组与对照组,每组40例。治疗组选用芪参通脉饮Ⅱ号方口服,对照组选用通塞脉片口服,两组均以14 d为1个疗程,共观察4个疗程。比较两组患者治疗前后中医症候积分、踝肱指数、视觉模拟评分法(VAS)疼痛评分及红外热像温度的变化情况,并比较两组总有效率。结果:治疗后的治疗组中医症候评分(5.28±3.27)分较观察组(6.65±2.68)低,差异有统计学意义(P<0.05);治疗后的治疗组踝肱指数为(0.72±0.08),高于对照组(0.68±0.06),差异有统计学意义(P<0.05);治疗后的红外热像温度变化情况为治疗组下肢左侧、右侧各部位足部温度高于观察组,治疗前后以及组间比较差异均有统计学意义(P<0.05);治疗后的治疗组VAS疼痛评分为(3.80±1.24)分,较观察组(4.60±1.01)分低,差异有统计学意义(P<0.05);治疗组临床总有效率为(82.5%),高于对照组(65.0%),差异有统计学意义(P<0.05)。结论:芪参通脉饮Ⅱ号方可有效缓解气血两虚、络脉瘀阻证型糖尿病足患者间歇性跛行、下肢疼痛、乏力等临床症状。Objective To investigate the clinical effect of Qishen Tongmai decoctionⅡin diabetic foot.Methods 80 patients with diabetic foot treated in our hospital were analyzed,and 40 patients from the treatment group and the control group and the control group received 14 d for 4 courses of treatment.The changes of TCM syndrome integral,ankle-brachial index,VAS pain score,and infrared thermal image temperature before and after treatment were compared between the two groups,and observed the total response rate,and the statistical analysis was conducted.Results After the treatment,the TCM syndrome score(5.28±3.27)was lower than that of the observed group(6.65±2.68).After treatment,the ankle-brachial index of(0.72±0.08)was higher than the control group(0.68±0.06),and the difference was significant(P<0.05).After treatment,the infrared thermal image of the foot temperature in the left and right parts of the lower limbs in the treatment group was higher than that of the observation group.After the comparison before and after treatment,the difference was statistically significant(P<0.05).After treatment,the VAS score(3.80±1.24)was lower than the observed group(4.06±1.01),and the difference was statistically significant(P<0.05).The total clinical response rate of the treatment group was(82.5%),which was higher than that of the control group(65.0%),and the difference was statistically significant(P<0.05).Conclusion Qishen Tongmai decoctionⅡcan effectively relieve qi and blood deficiency,intermittent claudication,lower limb pain,fatigue and other clinical symptoms.
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