基于Logistic回归分析合并家族史的食管癌发病危险因素  

Analysis of Risk Factors for Esophageal Carcinoma with Family History Based on Logistic Regression

作　　者：张瑞[1] 张亚玲[1] 陈玉龙[1] 宋学坤[1] 代民涛 徐学琴[1] 董玉琼[1] 马纯政[2] 解英[3] 舒琦瑾[4] 薛文翰[5] 李平[6] 范焕芳[7] 罗保平[8] 郑智[9] 李晓龙 张洪亮 周超峰 许彦超 李小青 王泽坤 朱然培 张华[1] 周哲旭 张帆[1] 郑玉玲[1] ZHANG Rui;ZHANG Yaling;CHEN Yulong;SONG Xuekun;DAI Mintao;XU Xueqin;DONG Yuqiong;MA Chunzheng;XIE Ying;SHU Qijin;XUE Wenhan;LI Ping;FAN Huanfang;LUO Baoping;ZHENG Zhi;LI Xiaolong;ZHANG Hongliang;ZHOU Chaofeng;XU Yanchao;LI Xiaoqing;WANG Zekun;ZHU Ranpei;ZHANG Hua;ZHOU Zhexu;ZHANG Fan;ZHENG Yuling(Henan University of Chinese Medicine,Zhengzhou Henan China 450046;The Second Affiliated Hospital of Henan University of Chinese Medicine/Henan Province Hospital of Traditional Chinese Medicine,Zhengzhou Henan China 450002;Shanxi Provincial Cancer Hospital,Taiyuan Shanxi China 030013;Zhejiang Provincial Hospital of Chinese Medicine,Hangzhou Zhejiang China 310006;Gansu Provincial Cancer Hospital,Lanzhou Gansu China 730000;The First Affiliated Hospital Of Anhui Medical University,Hefei Anhui China 230000;Hebei Province Hospital of Traditional Chinese Medicine,Shijiazhuang Hebei China 050000;Hubei Province Hospital of Traditional Chinese Medicine,Wuhan Hubei China 430061;Jiangxi Cancer Hospital,Nanchang Jiangxi China 330029;Ningxia Chinese Medicine Research Center,Yinchuan Ningxia China 750021;Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region,Wulumuqi Xinjiang China 830000)

机构地区：[1]河南中医药大学,河南郑州450046 [2]河南中医药大学第二附属医院/河南省中医院,河南郑州450002 [3]山西省肿瘤医院,山西太原030013 [4]浙江省中医院,浙江杭州310006 [5]甘肃省肿瘤医院,甘肃兰州730000 [6]安徽医科大学第一附属医院,安徽合肥230000 [7]河北省中医院,河北石家庄050000 [8]湖北省中医院,湖北武汉430061 [9]江西省肿瘤医院,江西南昌330029 [10]宁夏回族自治区中医医院暨中医研究院,宁夏银川750021 [11]新疆维吾尔自治区中医医院,新疆乌鲁木齐830000

出　　处：《中医学报》2022年第12期2587-2592,共6页Acta Chinese Medicine

基　　金：国家中医临床研究基地科研专项资助项目(2019JDZX001,2019JDZX028);国家中医药百千万人才支持计划-岐黄学者资助项目{国中医药人教发〔2018〕284号};河南省科技攻关社会发展项目(202102310497);河南省高等学校重点科研项目(20A360005)。

摘　　要：目的:分析合并家族史的食管癌发病的危险因素。方法:采用病例对照研究方法,2020年6月至2021年3月在全国10个省份对合并食管癌家族史的129例患者和88例对照人群进行调查。调查内容包括一般信息(基本信息、基本情况)、疾病史、食管癌家族史、个人膳食习惯、生活习惯与生活环境等。结果:采用非条件Logistic回归模型对资料进行分析,单因素分析结果:病例组与对照组在胃炎史、胃十二指肠溃疡史、口腔疾病、膳食口味、食热烫食物、吃质硬食物、食用腌菜、霉变食物、食用油摄入、吸烟情况、饮酒情况、口腔清洁情况、居住环境及堆制农家肥等方面比较,差异均有统计学意义(均P<0.05);多因素分析:年龄、胃炎史、口腔疾病史、食用腌菜与具有食管癌家族史的食管癌发病风险增高相关(P<0.05)[年龄≥60岁,OR=9.46,95%CI(2.60,34.38)、口腔疾病史OR=9.18,95%CI(1.63,51.85)、胃炎史OR=23.19,95%CI(5.47,98.39)、食用腌菜OR=11.66,95%CI(1.93,70.41)]。结论:高龄、口腔疾病、胃炎、食用腌菜可能是合并家族史的食管癌发病的高危因素。Objective:To analyze the risk factors of esophageal carcinoma with family history.Methods:Using the case-control study method,129 patients with family history of esophageal carcinoma and 88 controls were investigated in 10 provinces across the country from June 2020 to March 2021.The survey contents include general information(basic information,basic situation),disease history,family history of esophageal carcinoma,personal dietary habits,living habits,and living environment.Results:Unconditional Logistic regression model was used to analyze the data,and the results of the univariate analysis were as follows:There were significant differences between the case group and the control group in the history of gastritis,history of gastroduodenal ulcer,oral disease,dietary taste,eating hot food,eating hard food,eating pickled vegetables,moldy food,edible oil intake,smoking,drinking,oral hygiene,living environment and composting farmyard manure,etc.(P<0.05).Multivariate analysis:Age,history of gastritis,history of oral disease,and consumption of pickled vegetables were associated with an increased risk of EC with a family history(P<0.05).[Age(≥60 years old,OR=9.46,95%CI:2.60-34.38),history of oral disease(OR=9.18,95%CI:1.63-51.85),history of gastritis(OR=23.19,95%CI:5.47-98.39),edible pickles(OR=11.66,95%CI:1.93-70.41)].Conclusion:Old age,oral disease,gastritis,and consumption of pickled vegetables may be high-risk factors for EC with family history.

关 键 词：食管癌 家族史 危险因素 LOGISTIC回归 

分 类 号：R273.351[医药卫生—中西医结合]