2015—2021年浙江省MTB/HIV双重感染筛查现况及趋势分析  

Analysis on the current status and trend of MTB/HIV co-infection screening in Zhejiang Province from 2015 to 2021

作　　者：罗丹 陈松华[2] 张钰[2] 王伟[2] 吴倩 吴勇浩 刘魁[2] 陈彬[2] Luo Dan;Chen Songhua;Zhang Yu;Wang Wei;Wu Qian;Wu Yonghao;Liu Kui;Chen Bin(School of Public Health,Hangzhou Medical College,Hangzhou 310053,China;Department of Tuberculosis Control and Prevention,Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310051,China;School of Public Health,Zhejiang University,Hangzhou 310058,China)

机构地区：[1]杭州医学院公共卫生学院,杭州310053 [2]浙江省疾病预防控制中心结核病预防控制所,杭州310051 [3]浙江大学公共卫生学院流行病学与卫生统计学系,杭州310058

出　　处：《结核与肺部疾病杂志》2022年第6期443-448,共6页Journal of Tuberculosis and Lung Disease

基　　金：浙江省医药卫生科技计划项目(2021KY618,2020KY520)。

摘　　要：目的:分析浙江省2015—2021年MTB/HIV双重感染筛查情况,为制定和调整相应防控政策提供科学依据。方法:从《浙江省MTB/HIV双重感染防治管理工作年度报表》中收集2015—2021年浙江省MTB/HIV双重感染者相关资料,采用Excel 2010软件对数据进行整理和计算;用JoinPoint软件对双重感染检测率和检出率的拐点进行识别;使用ArcGIS 10.8软件绘制空间分布地图并对结果进行可视化展示;使用R软件对组间差异的比较进行分析。结果:2015—2021年,浙江省共发现MTB/HIV双重感染者773例,99.74%(771/773)的患者年龄>15岁,90.94%(703/773)的双重感染者接受抗结核治疗,金华市和温州市患者数分别为149例和146例,为浙江省双重感染高发地区。结核病患者中的HIV抗体检测率在7年间呈现升高的趋势(APC=4.9,P<0.05),HIV/AIDS患者中的结核病检出率呈降低的趋势(APC=-15.5,P<0.05)。结论:浙江省2015—2021年开展MTB/HIV双重感染筛查工作,对双重感染患者的早期发现和督导治疗具有一定效果,还需提高HIV/AIDS患者中的结核病检查率,金华市和温州市应因地制宜,加强双重感染疫情防控力度。Objective:To analyze the screening of MTB/HIV co-infection in Zhejiang Province from 2015 to 2021,so as to provide scientific basis for formulating and adjusting corresponding prevention and control policies.Methods:The relevant data of MTB/HIV co-infection in Zhejiang Province from 2015 to 2021 were collected from the Annual Report of Prevention and Management of MTB/HIV co-infection in Zhejiang Province.Excel 2010 software was used to organize and calculate the data.JoinPoint software was used to identify the inflection points of double infection detection rate and positive rate.ArcGIS 10.8 software was used to draw the spatial distribution map and visualize the results.R software was used to compare the differences between groups.Results:A total of 773 patients with double infection were found in Zhejiang Province from 2015 to 2021,771 patients(99.74%,771/773)were over 15 years old,90.94%(703/773)of the patients received tuberculosis treatment.Jinhua and Wenzhou were the areas with high incidence of double infection in Zhejiang Province,numbers of patients were 149 and 146,respectively.The detection rate of HIV screening in tuberculosis patients increased in the past seven years(APC=4.9,P<0.05),while the positive detection rate in HIV/AIDS patients showed a trend of decrease(APC=-15.5,P<0.05).Conclusion:The MTB/HIV co-infection screening in Zhejiang Province from 2015 to 2021 has a certain effect on the early detection and treatment of patients with co-infection.The screening rate of tuberculosis among HIV/AIDS patients should be improved,Jinhua and Wenzhou should strengthen the prevention and control of co-infection epidemic situation according to local conditions.

关 键 词：分枝杆菌 结核 HIV感染 共病现象 流行病学研究 

分 类 号：R52[医药卫生—内科学] R512.91[医药卫生—临床医学] R181