耐多药结核病患者密切接触者结核分枝杆菌潜伏感染的诊治现状与展望  

Current status and prospect of screening and treatment of latent multidrug-resistant tuberculosis infection

作　　者：陈秋奇 吴超玲 张培泽 邓国防 Chen Qiuqi;Wu Chaoling;Zhang Peize;Deng Guofang(Graduate School of Guangdong Medical University,Guangdong Province,Zhanjiang 524023,China;The First Clinical Medical College of Gannan Medical University,Jiangxi Province,Ganzhou 341000,China;The Second Department of Pulmonary Diseases,Shenzhen Third People’s Hospital Affiliated to Guangdong Medical University,Guangdong Province,Shenzhen 518112,China)

机构地区：[1]广东医科大学研究生院,湛江524023 [2]赣南医学院第一临床医学院,赣州341000 [3]广东医科大学附属深圳市第三人民医院肺病二科,深圳518112

出　　处：《结核与肺部疾病杂志》2022年第6期517-520,共4页Journal of Tuberculosis and Lung Disease

基　　金：国家自然科学基金(82070016);佛山市第四人民医院“登峰计划”高水平医院建设开放课题(FSSYKF-2020001);结核病宿主反应检测技术在肺结核疗效评价中的应用研究(G2022005);结核分枝杆菌体内异质性机制及其对结核病临床预后的影响研究(G2021015)。

摘　　要：耐多药结核病患者的密切接触者感染耐多药结核分枝杆菌的风险较高,部分患者易罹患耐多药结核分枝杆菌相关的潜伏感染,是管控结核病的重点人群。目前,对耐多药结核分枝杆菌潜伏感染的筛查方法存在不足,预防性治疗的目标人群和治疗方案仍不完全明确。笔者就耐多药结核分枝杆菌潜伏感染的流行病学、筛查策略和预防性治疗策略等方面的进展进行综述,以加强临床医生的认识。Close contacts with multidrug-resistant tuberculosis(MDR-TB)patients have a high risk of MDR-TB infection.Some of them are prone to develop latent MDR-TB infections so that they will become a key population for tuberculosis management and control.At present,the screening and treatment of latent MDR-TB infection are challenging and still unclear.Therefore,we reviewed the epidemic and the evidence of screening,management or prevention in close contact with MDR-TB.

关 键 词：结核 抗多种药物性 接触者追踪 诊断 治疗学 

分 类 号：R52[医药卫生—内科学]