器官移植术后患者接种新型冠状病毒肺炎疫苗的研究进展  

Research progress of COVID‑19 vaccination in organ transplant recipients

作　　者：徐玮晨 周大为[1] 梁峻滔 叶啟发[1,3] XU Weichen;ZHOU Dawei;LIANG Juntao;YE Qifa(Zhongnan Hospital of Wuhan University,Institute of Hepatobiliary Diseases of Wuhan University,Transplant Center of Wuhan University,&Hubei Key Laboratory of Medical Technology on Transplantation,Wuhan 430071,Hubei,China;Renmin Hospital of Wuhan University&The First Clinical College of Wuhan University,Wuhan 430060,Hubei,China;Dept.of Transplant Surgery,The Third Xiangya Hospital,Central South University,Changsha 410013,Hunan,China)

机构地区：[1]武汉大学中南医院/武汉大学肝胆疾病研究院/武汉大学移植医学中心/移植医学技术湖北省重点实验室,湖北武汉430071 [2]武汉大学人民医院/武汉大学第一临床学院,湖北武汉430060 [3]中南大学湘雅三医院/卫生部移植医学工程技术研究中心,湖南长沙410013

出　　处：《武汉大学学报（医学版）》2022年第6期869-873,共5页Medical Journal of Wuhan University

基　　金：国家自然科学基金资助项目(编号:81970548);医学腾飞计划⁃“转化医学、医学+平台建设项目”(临床医学)(编号:TFLC2018003)。

摘　　要：新型冠状病毒肺炎(新冠肺炎)疫情随着新型冠状病毒肺炎疫苗(新冠疫苗)的普及在全世界范围内逐渐好转,但是新冠肺炎给器官移植术后患者带来的健康风险尚未结束,因为这类人群需要终生进行免疫抑制治疗,接种疫苗的有效性与安全性往往低于正常人群。但目前我国已投入使用的新冠疫苗尚未对这类免疫抑制人群进行临床试验,其有效性与安全性尚未获得临床验证。因此,本文对器官移植术后患者疫苗接种的现状及理念和我国已投入使用的新冠疫苗有效性和安全性进行综述,为这类患者接种新冠疫苗提供理论依据,以期降低这类患者的新冠病毒感染风险。The pandemic has been relieved all over the world with the popularity of the COVID⁃19 vaccine.However,transplant recipients are still at risk of COVID⁃19 because they require lifelong immunosuppressive therapy,and the effectiveness and safety of vaccination are often lower than that of the normal population.Meanwhile,the effectiveness and safety of COVID⁃19 vaccination have not yet been demonstrated in the immunosuppressive population,due to the lack of proper clinical trials on this group.Therefore,the present study reviews the current situation and concept of vaccination for patients after organ transplantation,and the effectiveness and safety of the new coronavirus vaccine which has been put into use in China,so as to provide a theoretical basis for the vaccination of COVID⁃19 vaccine for these patients,and to reduce the risk of COVID⁃19 infection in these patients.

关 键 词：器官移植 免疫抑制 疫苗 新型冠状病毒肺炎 

分 类 号：R330.21[医药卫生—人体生理学]