Profiling spatial gene activity in marmoset embryos  

作　　者：Guangdun Peng Patrick P.L.Tam 

机构地区：[1]Center for Cell Lineage and Development,CAS Key Laboratory of Regenerative Biology,Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine,GIBHHKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Guangzhou,Guangdong,China [2]Embryology Research Unit,Children’s Medical Research Institute,and School of Medical Sciences,Faculty of Medicine and Health,University of Sydney,Sydney,NSW 2145,Australia.

出　　处：《Cell Research》2022年第10期873-874,共2页细胞研究（英文版）

摘　　要：Spatial transcriptomics of the marmoset embryo unveils insights into the molecular landscape of post-implantation development and provides a reference dataset of cell and tissue identity and the mechanistic attributes of germ layer formation.The knowledge gains of the developmental coordinates of early gastrulation point to the utility of this non-human primate for modeling post-implantation development of human embryos.The wealth of knowledge of the developmental biology of the mouse has hallmarked the laboratory mouse as a model organism for mammalian development.Significant progress has been achieved,through the analysis of genome function in geneperturbation experimentation and the profiling of omics attributes of cell populations in developing embryos,in delineating morphogenetic mechanism,cell lineage trajectory and molecular drivers underpinning the development of preimplantation and early post-implantation mouse embryo.

关 键 词：IMPLANTATION KNOWLEDGE LANDSCAPE 

分 类 号：Q95[生物学—动物学]