氨甲环酸联合缩宫素预防剖宫产产后出血的效果分析  

Effect Analysis of Tranexamic Acid Combined with Oxytocin in Preventing Postpartum Hemorrhage After Cesarean Section

作　　者：谭欢 TAN Huan(District 1 of Obstetrics and Gynecology,Ningde People's Hospital,Ningde 352100,Fujian Province,China)

机构地区：[1]宁德人民医院妇产科一区,福建宁德352100

出　　处：《罕少疾病杂志》2022年第12期72-73,共2页Journal of Rare and Uncommon Diseases

摘　　要：目的本研究旨在探究氨甲环酸(TXA)联用缩宫素用以预防产妇剖宫产产后出血(PPH)的治疗效果。方法选择2020年12月至2021年12月宁德人民医院妇产科的110例剖宫产产妇分为研究对象,使用随机数字表法将剖宫产产妇对照组和试验组,各55例。两组均行子宫下段横切口剖宫产,对照组使用缩宫素预防PPH,试验组同时联合TXA预防PPH。对比两组的产后出血情况(产后2h出血量、产后24h出血量)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(FIB))、不良反应(恶心、呕吐、腹泻、胸闷、面部潮红)。结果试验组的产后2h出血量、产后24h出血量均低于对照组,试验组的产妇产后出血率为5.45%远低于对照组的18.18%(P<0.05),术前两组的APTT、PT、FIB比较其差异并无明显的统计学意义(P>0.05),术后试验组的APTT、PT短于对照组,FIB高于对照组(P<0.05),试验组的不良反应总发生率为14.54%与对照组16.36%的不良反应总发生率比较,其差异无明显的统计学意义(P>0.05)。结论TXA联用缩宫素预防剖宫产PPH用以预防产妇剖宫产产后出血的效果显著,能够明显降低产妇剖宫产产后出血率,改善凝血功能指标,安全性好,值得应用。Objective This study investigated the effect of tranexamic acid(TXA)combined with oxytocin in preventing postpartum hemorrhage(PPH)after cesarean section.Methods A total of 110 cesarean section women from the Department of Obstetrics and Gynecology of Ningde People's Hospital from December 2020 to December 2021 were selected and divided into the research objects.The control group and the experimental group of cesarean section women were divided into the control group and the experimental group by using the random number table method,with 55 cases in each.Both groups underwent cesarean section with transverse incision in the lower uterine segment.The control group was given oxytocin to prevent PPH,while the experimental group was combined with TXA to prevent PPH.Postpartum hemorrhage(2h postpartum hemorrhage volume,24h postpartum hemorrhage volume),coagulation function indexes(activated partial thromboplastin time(APTT),prothrombin time(PT),fibrinogen(FIB),adverse events were compared between the two groups.Reactions(nausea,vomiting,diarrhea,chest tightness,facial flushing).Results The postpartum hemorrhage volume and 24h postpartum hemorrhage volume of the experimental group were lower than those of the control group,and the postpartum hemorrhage rate of the experimental group(5.45%)was lower than that of the control group(18.18%)(P<0.05).There was no significant difference in PT and FIB(P>0.05).After operation,APTT and PT in the experimental group were shorter than those in the control group,and FIB was higher than that in the control group(P<0.05).The total incidence of adverse reactions in the experimental group was 14.54%.)and the control group(16.36%)had no significant difference(P>0.05).Conclusion TXA combined with oxytocin has a promising effect on preventing PPH in cesarean section,can significantly reduce the rate of postpartum hemorrhage,and improve the coagulation function index.It has good safety and is worthy of application.

关 键 词：氨甲环酸(TXA) 缩宫素 剖宫产 产后出血 

分 类 号：R714.12[医药卫生—妇产科学]