新生儿出生时血脂水平与胎龄、出生体重的相关性研究  

Correlation Between Lipid Profiles in Neonates with Different Gestational Age and Birth Weight

作　　者：郑青青[1,2,3] 庄根苗 刘登礼 ZHENG Qing-qing;ZHUANG Gen-miao;LIU Deng-li(Department of Pediatrics,the First Affiliated Hospital of Xiamen University,Xiamen 361003,Fujian Province,China;Pediatric Key Laboratory of Xiamen,Xiamen 361003,Fujian Province,China;Institute of Pediatrics,School of Medicine,Xiamen University,Xiamen 361003,Fujian Province,China)

机构地区：[1]厦门大学附属第一医院儿科,福建厦门361003 [2]厦门市儿科重点实验室,福建厦门361003 [3]厦门大学医学院儿童医学研究所,福建厦门361003

出　　处：《罕少疾病杂志》2022年第12期107-109,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨新生儿出生时血脂水平与胎龄、出生体重的相关性。方法选择2018年1月至2018年7月本院新生儿科收治的新生儿共363例,检测出生0~24小时血浆总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A1(Apo-A1)和载脂蛋白B(Apo-B)水平。比较不同胎龄、出生体重新生儿间血脂水平差异,对血脂与胎龄、出生体重行相关性分析。结果(1)根据胎龄分为三组:<34周(n=43例),34~36周(n=125例)和≥37周(n=195例),三组间TC、TG、LDL-C、HDL-C和Apo-B差异有统计学意义。(2)按出生体重分为三组:<1500g(n=23例),1500~2499g(n=116例)和≥2500g(n=224例)。三组间6个指标差异均有统计学意义。结论TG与胎龄成正相关,TC、LDL-C、HDL-C和Apo-B与胎龄成负相关。TG、Apo-A1与出生体重成正相关,TC、LDL-C、HDL-C和Apo-B与出生体重成负相关。Objective To investigate the correlation between lipid in neonates with gestational ages and birth weights.Methods A total of 363 neonates admitted to the neonatal intensive care unit of the First Affiliated Hospital of Xiamen University from January 2018 to March 2018 were selected,and plasma total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),apolipoprotein A1(Apo-A1)and apolipoprotein B(Apo-B)were measured from 0 to 24 hours after birth.The results were compared and the correlation was analyzed based on gestational ages and birth weights of the neonates.Results(1)Three groups were divided according to different gestational ages:<34 weeks(n=43),34~36 weeks(n=125),and≥37 weeks(n=195).There were significant differences among the three groups in TC(2.62±0.95,1.99±0.57,1.66±0.44,mmol/L),TG(0.35±0.15,0.44±0.24,0.58±0.22,mmol/L),LDL-C(1.06±0.49,0.71±0.29,0.56±0.18,mmol/L),HDL-C(0.94±0.26,0.83±0.23,0.74±0.22,mmol/L),or Apo-B(0.40±0.15,0.29±0.09,0.26±0.06,g/L)(P<0.01).TG was positively correlated with gestational ages(r=0.335,P<0.01),while TC,LDL-C,HDL-C,and Apo-B were negatively correlated with gestational ages(r=-0.415,-0.448,-0.224,-0.386,P<0.01).There was not statistically significant difference among the three groups for Apo-A1.(2)Three groups were divided according to different birth weights:<1500g(n=23),1500~2499g(n=116),and≥2500g(n=224).There were significant differences among the three groups in TC(2.48±1.05,2.05±0.73,1.75±0.47,mmol/L),TG(0.39±0.19,0.47±0.29,0.53±0.20,mmol/L),LDL-C(1.03±0.51,0.75±0.37,0.60±0.20,mmol/L),HDL-C(0.81±0.25,0.84±0.26,0.77±0.22,mmol/L),Apo-A1(0.74±0.14,0.81±0.13,0.82±0.14,g/L)or Apo-B(0.41±0.16,0.30±0.10,0.27±0.07,g/L)(P<0.01 or 0.05).TG and Apo-A1 was positively correlated with birth weights(r=0.168,0.130,P<0.01 or 0.05),while TC,LDL-C,HDL-C,and Apo-B were negatively correlated with birth weights(r=-0.323,-0.373,-0.125,-0.353,P<0.01 or 0.05).Conclusion Neonatal TG increased

关 键 词：血脂 新生儿 胎龄 出生体重 

分 类 号：R722[医药卫生—儿科]