Exploration of biocompatible AIEgens from human trichochrome  

由人类毛发红素结构改造的生物相容性聚集诱导发光体系

作　　者：Qiguang Zang Jie Zhang Chenyang Huang Haoke Zhang Jianzhao Liu Jing Zhi Sun Ben Zhong Tang 臧启光;张洁;黄晨旸;张浩可;刘建钊;孙景志;唐本忠(MOE Key Laboratory of Macromolecules Synthesis and Functionalization,Department of Polymer Science and Engineering,Zhejiang University,Hangzhou 310027,China;Institute of Health Materials of Zhejiang University&Shaoxing City,Shaoxing 312000,China;ZJU-Hangzhou Global Scientific and Technological Innovation Center,Hangzhou 311215,China;Shenzhen Institute of Aggregate Science and Technology,School of Science and Engineering,The Chinese University of Hong Kong,Shenzhen 518172,China)

机构地区：[1]MOE Key Laboratory of Macromolecules Synthesis and Functionalization,Department of Polymer Science and Engineering,Zhejiang University,Hangzhou 310027,China [2]Institute of Health Materials of Zhejiang University&Shaoxing City,Shaoxing 312000,China [3]ZJU-Hangzhou Global Scientific and Technological Innovation Center,Hangzhou 311215,China [4]Shenzhen Institute of Aggregate Science and Technology,School of Science and Engineering,The Chinese University of Hong Kong,Shenzhen 518172,China

出　　处：《Science China Materials》2022年第11期3175-3181,共7页中国科学（材料科学（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(22021715 and 52150222);the Major Scientific and Technological Project of the Department of Science&Technology,Zhejiang Province(2020C03030);the support from the Open Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates and the South China University of Technology(2019B030301003)。

摘　　要：Natural chromophores wildly exist in living bodies and have been utilized for thousands of years[1].Many of them,such as quinine[2],luciferin[3-5],coelenteramide[6,7],and coumarin[8],can fluoresce and have been widely applied in biosensor,immune sensor,and fluorescent imaging agents[9,10].人类毛发红素(HTC)是一类生物安全性高、环境友好、性能稳定的天然色素,然而HTC的核心结构BBTD在溶解状态和固态下均无荧光发射.通过结构测试结合理论计算,我们揭示了该化合物独特的双重暗态光物理特性的内在机理.在深刻理解机理的基础上,我们利用化学修饰的手段改造了BBTD母核,设计合成了一系列具有聚集诱导发射光性质的BBTD衍生物,并成功将其应用于溶酶体靶向成像以及DN A定量检测领域.

关 键 词：聚集诱导发光 结构测试 生物安全性 生物相容性 溶解状态 光物理特性 结构改造 设计合成 

分 类 号：TB34[一般工业技术—材料科学与工程]