Mechanisms of chromatin-based epigenetic inheritance  

作　　者：Wenlong Du Guojun Shi Chun-Min Shan Zhiming Li Bing Zhu Songtao Jia Qing Li Zhiguo Zhang 

机构地区：[1]National Laboratory of Biomacromolecules,CAS Center for Excellence in Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing10010l,China [2]State Key Laboratory of Protein and Plant Gene Research,School of Life Sciences and Peking-Tsinghua Center for Life Sciences,Peking University,Beijing10087l,China [3]State Key Laboratory of Plant Genomics,Institute of Microbiology,Chinese Academy of Sciences,Bejing 100101,China [4]Institutes of Cancer Genetics,Herbert Irving Comprehensive Cancer Center,Columbia University Medical Center,New York,NY10032,USA [5]College of Life Sciences,University of Chinese Academy of Sciences,Bejing 100049,China [6]Department of Biological Sciences,Columbia Universiy.New York,NY 10027,USA

出　　处：《Science China(Life Sciences)》2022年第11期2162-2190,共29页中国科学（生命科学英文版）

基　　金：the National Natural Science Foundation of China(31725015,31830048 to Q.L.and 32000417 to W.D.);the Beijing Outstanding Young Scientist Program(BJJWZYJH01201910001005 to Q.L.);the National Key Research and Development Project of China(2019YFA0508903 to Q.L.);the China Postdoctoral Science Foundation(2020M670487 to W.D.);the Chinese Academy of Sciences(XDB 37010100 and QYZDY-SSW-SMC031 to B.Z.);the K.C.Wong educational foundation(GJTD-2020-06 to B.Z.);the National Institutes of Health(R35 GM126910 to S.J.and R35 GM115018 to Z.Z.)。

摘　　要：Multi-cellular organisms such as humans contain hundreds of cell types that share the same genetic information(DNA sequences),and yet have different cellular traits and functions.While how genetic information is passed through generations has been extensively characterized,it remains largely obscure how epigenetic information encoded by chromatin regulates the passage of certain traits,gene expression states and cell identity during mitotic cell divisions,and even through meiosis.In this review,we will summarize the recent advances on molecular mechanisms of epigenetic inheritance,discuss the potential impacts of epigenetic inheritance during normal development and in some disease conditions,and outline future research directions for this challenging,but exciting field.

关 键 词：epigenetic inheritance histone modification DNA methylation histone deposition DNA replication 

分 类 号：Q343.2[生物学—遗传学]