Enzymatic and chemo-enzymatic strategies to produce highly valuable chiral amines from biomass withω-transaminases on 2D zeolites  

作　　者：J.Miguel Carceller Karen S.Arias Maria J.Climent Sara Iborra Avelino Corma 

机构地区：[1]Instituto de Tecnologia Química(UPV-CSIC),Universitat Politècnica de València,Valencia 46022,Spain

出　　处：《National Science Review》2022年第9期5-13,共9页国家科学评论（英文版）

基　　金：supported by the Spanish Government through the‘Severo Ochoa Program’(SEV-2016–0683);the PGC2018-097277-B-100(MCIU/AEI/FEDER,UE)Project。

摘　　要：Amino transaminases(ATAs)have been supported on a 2D ITQ-2 zeolite through electrostatic interactions,resulting in a highly stable active biocatalyst to obtain a variety of valuable chiral amines starting from prochiral ketones derived from biomass.We have extended the biocatalyst applications by designing a chemo-enzymatic process that allows,as the first step,prochiral ketones to be obtained from biomass-derived compounds through an aldol condensation–reduction step using a bifunctional metal/base catalyst.The prochiral ketone is subsequently converted into the chiral amine using the immobilized ATA.We show that it is feasible to couple both steps in a semi-continuous process to produce industrially relevant chiral amines with yields of>95%and~100%enantiomer excess.

关 键 词：amino transaminase ITQ-2 zeolite chemo-enzymatic process BIOMASS semi-continuous process Pd/MgO 

分 类 号：TQ426[化学工程]