(苯-1,3,5-三酰基)三乙腈的合成  

Synthsis of (Benzene-1,3,5-triyl)triacetonitrile

作　　者：陈艳君[1] 彭振博[1] 李爱元[1] 杨伟群[1] 汪泠 周家豪 Chen Yanjun;Peng Zhenbo;Li Aiyuan;Yang Weiqun;Wang Ling;Zhou Jiahao(Zhejiang Collaborative Innovation Center for High Value Utilization of Byproducts from Ethylene Project,Collegeof Chemical Engineering,Ningbo Polytechnic,Ningbo,Zhejiang315800,China)

机构地区：[1]宁波职业技术学院乙烯工程副产物高质化利用浙江省应用技术协同创新中心化学工程学院,浙江宁波315800

出　　处：《化学世界》2022年第5期298-301,共4页Chemical World

基　　金：宁波职业技术学院校级课题(No.NZ20C001);浙江省教育厅一般科研(No.Y201941131);浙江省2019年度高校国内访问工程师“校企合作项目”(No.FG2019041);2020年浙江省大学生科技创新活动计划(新苗人才计划)(No.2020R477012)资助项目。

摘　　要：以1,3,5-三(溴甲基)苯和氰化钾为原料,4-二甲氨基吡啶催化作用下,经亲核取代反应制得目标化合物。产物结构经~1H NMR、IR和电子碰撞质谱法(EI-MS)确证。通过对反应条件研究,确定了最佳反应条件为:n(1,3,5-三(溴甲基)苯)∶n(KCN)=1∶3.1,二甲基亚砜(DMSO)和水为反应溶剂,n(4-二甲氨基吡啶)∶n(1,3,5-三(溴甲基)苯)=0.05,40℃反应2 h,产物收率为97%。(Benzene-1,3,5-triyl)triacetonitrile was synthesized from 1,3,5-tri(bromomethyl)benzene with potassium cyanide, catalyzed by 4-dimethylamino pyridine. The structure of product was confirmed by ~1H NMR, IR and electron impact mass spectra(EI-MS). The optimal reaction conditions were investigated. The results showed that the target product was obtained in a yield of 97% under the conditions of n(1,3,5-tri(bromomethyl)benzene)∶n(KCN)=1∶3.1 in the mixture of dimethyl sulfoxide(DMSO) and water, n(4-dimethylamino pyridine)∶n(1,3,5-tri(bromomethyl)benzene)=0.05, at 40 ℃ for 2 h.

关 键 词：(苯-1 3 5-三酰基)三乙腈 氰化钾 4-二甲氨基吡啶 合成 

分 类 号：O621.3[理学—有机化学] O625.6[理学—化学]