1例甲状旁腺功能减退性心肌病患者的药学监护  

Pharmaceutical care of one case of hypoparathyroid cardiomyopathy

作　　者：李友佳[1,2] 谢姣 姚红伊[2,3] 计成 LI Youjia;XIE Jiao;YAO Hongyi;JI Cheng(Department of Pharmacy,the Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an Shaanxi 710004,China;Department of Endocrinology,the Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing Jiangsu 210008,China;Department of Pharmacy,the Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou Zhejiang 310009,China;Department of Pharmacy,the Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing Jiangsu 210008,China)

机构地区：[1]西安交通大学第二附属医院药学部,陕西西安710004 [2]南京大学医学院附属鼓楼医院内分泌科,江苏南京210008 [3]浙江大学医学院附属第二医院药学部,浙江杭州310009 [4]南京大学医学院附属鼓楼医院药学部,江苏南京210008

出　　处：《中国药物警戒》2022年第11期1254-1257,共4页Chinese Journal of Pharmacovigilance

基　　金：国家自然科学基金资助项目(82003860);中国药学会科技开发中心科普项目(CMEI2020KPYJ(JZX)00412);西安交通大学第二附属医院青年项目(YJ(QN)201924)。

摘　　要：目的 探讨甲状旁腺功能减退性心肌病患者治疗方案,为临床合理用药提供参考。方法 检索国内外文献,结合本例临床药师对患者实施全程化药学监护的治疗过程,评价药物治疗合理性。结果 甲状旁腺功能减退性心肌病治疗的关键为血钙水平的提升,低钙难以纠正时,应及时增加补钙药物剂量;选择利尿剂时,避免使用袢利尿剂呋塞米,宜选用具有保钙作用的噻嗪类利尿剂(如氢氯噻嗪);同时纠正低镁血症,有助提高疗效。结论 临床药师参与到甲状旁腺功能减退性心肌病患者的治疗过程中,协助医师制定及优化治疗方案,实施全程化药学监护,有助于保障患者用药的安全、有效、合理。Objective To explore the treatment plan for one patient with hypoparathyroid cardiomyopathy, and to provide reference for clinical rational use of drugs. Methods The rationality of the medication was evaluated by combining the related literature with the pharmaceutical care of this patient. Results The increase of blood calcium levels was critical to the treatment of hypoparathyroid cardiomyopathy. Therefore, the dose of calcium supplements had to be increased once hypocalcemia was hard to improve. Hydrochlorothiazide, a thiazide diuretic with calcium-preserving effect, should be the candidate instead of furosemide. Meanwhile, improving hypomagnesemia contributed to the curative effect. Conclusion Pharmacists can help ensure the safety, effectiveness and rationality of drug use by participating in the treatment of patients with hypoparathyroid cardiomyopathy, assisting physicians in formulating and optimizing treatment plans, and implementing full-course pharmaceutical monitoring.

关 键 词：甲状旁腺功能减退 心肌病 药学监护 临床药师 合理用药 

分 类 号：R994.11[医药卫生—毒理学] R977[医药卫生—药学]