1例头孢他啶/阿维巴坦治疗碳青霉烯耐药肺炎克雷伯菌血流感染患者的药学监护  

Pharmaceutical care of a case of carbapenem resistant Klebsiella pneumoniae bloodstream infection treated with ceftazidime/verbatan

作　　者：任昭[1] 刘佳[1] 王玉敏 王月[1] 谢清[1] REN Zhao;LIU Jia;WANG Yumin;WANG Yue;XIE Qing(Department of Pharmacy,Aerospace Center Hospital,Beijing 100049,China;Department of Respiratory and Critical Care Medicine,Aerospace Center Hospital,Beijing 100049,China)

机构地区：[1]航天中心医院药剂科,北京100049 [2]航天中心医院呼吸与危重症医学科,北京100049

出　　处：《中国药物警戒》2022年第11期1258-1261,共4页Chinese Journal of Pharmacovigilance

基　　金：北京市海淀区卫生健康发展科研委培育计划(HP2021-19-50701)。

摘　　要：目的 探讨临床药师在碳青霉烯耐药肺炎克雷伯菌血流感染药物治疗中的作用。方法 临床药师参与1例碳青霉烯耐药肺炎克雷伯菌血流感染患者的治疗过程,结合专业知识,根据患者实际情况,建议采用注射用头孢他啶阿维巴坦单药治疗方案,并对用药的有效性和安全性进行监护。结果 医生采纳临床药师建议,经治疗后患者体温正常,炎症指标好转,血培养显示无细菌生长。结论 临床药师通过参与临床工作,及时掌握新药的相关知识,为临床医生提供药学信息服务,保障用药的合理性、安全性。Objective To investigate the role of clinical pharmacists in the treatment of bloodstream infection caused by carbapenem resistant Klebsiella pneumoniae. Methods Clinical pharmacists participated in the treatment of a patient with bloodstream infection caused by carbapenem resistant Klebsiella pneumoniae. Based on their expertise and the condition of the patient, the pharmacists recommended ceftazidime/avibactam monotherapy, and monitored the effectiveness and safety of medication. Results The clinicians took the advice of clinical pharmacists so that the patient’s temperature returned to normal, the inflammatory indexes were improved, and the blood culture showed no bacterial growth. Conclusion By participating in clinical practice, clinical pharmacists can quickly learn about the usage of new drugs, provide pharmaceutical services for clinicians, and ensure the rationality and safety of drug use.

关 键 词：肺炎克雷伯菌 碳青霉烯耐药 头孢他啶/阿维巴坦 药学监护 

分 类 号：R969.3[医药卫生—药理学]