基于加权逼近理想解排序法的儿科利奈唑胺药物利用评价  

Assessment of usage of linezolid by a pediatric department based on weighted TOPSIS method

作　　者：胡章海 杨万枝[1] HU Zhanghai;YANG Wanzhi(Anqing First People’s Hospital Affiliated to Anhui Medical University&Anqing First People’s Hospital,Anqing Anhui 246003,China)

机构地区：[1]安徽医科大学附属安庆第一人民医院,安庆市第一人民医院,安徽安庆246003

出　　处：《中国药物警戒》2022年第10期1128-1131,共4页Chinese Journal of Pharmacovigilance

基　　金：安庆市第一人民医院2022年“三新”立项项目(Y2022012)。

摘　　要：目的建立基于加权逼近理想解排序法(TOPSIS)的儿科利奈唑胺药物合理性应用评价标准,为儿科患者合理应用利奈唑胺提供参考。方法以利奈唑胺药品说明书为基础,依据《抗菌药物临床应用指导原则》(2015年版),参考相关专家共识及诊疗规范,建立基于加权TOPSIS法的儿科利奈唑胺药物利用评价细则,并以此为依据,对安庆市第一人民医院2020年9月1日至2021年3月31日共57例儿科患者利奈唑胺的应用情况进行合理性评价。结果评价的57份病历中,相对接近度(CI)为100%的有2例(3.51%),CI在80%~<100%的有3例(5.26%),CI在60%~<80%的有36例(63.16%),CI在50%~<60%的有16例(28.07%)。CI≥60%的有41例(71.93%)。结论基于加权TOPSIS法的儿科利奈唑胺药物利用评价标准可用于该药物儿科的合理性评价,评价结果显示该院儿科利奈唑胺使用基本合理,但医院需在会诊制度落实、用药疗程、用药后疗效评估及不良反应监测等方面进一步规范利奈唑胺的合理应用。Objective To establish a method based on the weighted technique for order preference by similarity to ideal solution(TOPSIS)method to assess the usage of linezolid by a pediatric department,and to provide reference for rational use of linezolid for pediatric patients.Methods Based on instructions about linezolid,expert consensus,related guidelines for diagnosis and treatment,and the TOPSIS method,explicit rules for assessment of the ways in which linezolid was prescribed by a pediatric department were established before the usage of linezolid among 57 pediatric patients in Anqing First People’s Hospital between September 1,2020 and March 31,2021 was assessed.Results Among the 57 cases,the relative approach degree was 100%in two cases(3.51%),ranged from 80%to less than 100%in three cases(5.26%),from 60%to less than 80%in thirty-six cases(63.16%),from 50%to less than 60%in sixteen cases(28.07%),and was 60%or above in 41 cases(71.93%).Conclusion The weighted TOPSIS method can be used to assess the usage of linezolid among pediatric patients.The results of assessment suggest that linezolid has been properly used in our hospital,but the rational use can be standardized in terms of consultations,duration of medication,evaluation of efficacy and monitoring of drug adverse reactions.

关 键 词：利奈唑胺 加权逼近理想解排序法 药物利用评价 儿科 

分 类 号：R911[医药卫生—药学] R978