降脂护肝汤治疗代谢相关脂肪性肝炎临床疗效及对肝脏抗氧化应激能力的影响  

Curative Effect of Jiangzhi Hugan Tang on Metabolism-Associated Steatohepatitis and Its Effect on Anti-Oxidative Stress Ability of Liver

作　　者：向晶 刘静[2] XIANG Jing;LIU Jing

机构地区：[1]浙江大学医学院附属金华医院感染性疾病科,浙江金华321000 [2]杭州师范大学附属医院肝病科,浙江杭州310000

出　　处：《新中医》2022年第19期105-109,共5页New Chinese Medicine

基　　金：2020年浙江省医药卫生科技计划项目(2020KY715)。

摘　　要：目的:观察降脂护肝汤对代谢相关脂肪性肝炎(MASH)的疗效及对肝脏抗氧化应激能力的影响。方法:采用随机数字表法将90例MASH患者分为对照组与观察组各45例。对照组采用常规治疗,观察组在对照组基础上加服降脂护肝汤。比较2组治疗前后中医证候积分、肝功能、血脂水平及氧化应激指标。结果:与同组治疗前比较,治疗后2组各项中医证候积分及血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、谷氨酰转肽酶(GGT)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、丙二醛(MDA)水平均降低(P<0.05),超氧化物歧化酶(SOD)水平升高(P<0.05);与对照组治疗后比较,观察组治疗后各中医证候积分及血清AST、ALT、GGT、TC、TG、LDL-C、MDA水平均较低(P<0.05),SOD水平较高(P<0.05)。结论:降脂护肝汤能有效减轻MASH患者氧化应激反应,增加其抗氧化能力,改善临床症状,具有较好的护肝降酶及改善血脂水平的作用。Objective: To observe the curative effect of the therapy of Jiangzhi Hugan tang on metabolism-associated steatohepatitis(MASH) and its effect on anti-oxidative stress ability of liver.Methods: A total of 90 patients with MASH were selected and divided into the control group and the observation group according to the random number table method,with 45 cases in each group. The control group was treated with routine treatment,and the observation group was additionally treated with Jiangzhi Hugan tang based on the treatment of the control group. Before and after treatment,the Chinese medicine syndrome scores, liver function, levels of blood lipid and indexes of oxidative stress were compared between the two groups. Results:After treatment,the Chinese medicine syndrome scores and levels of serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),γ-glutamyl transpeptidase(GGT),total cholesterol(TC), triglyceride(TG), low-density lipoprotein cholesterol(LDL-C) and malondialdehyde(MDA) in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of superoxide dismutase(SOD) were increased(P<0.05);after treatment, each Chinese medicine syndrome score and levels of AST,ALT,GGT,TC,TG,LDL-C and MDA in the observation group were lower than those in the control group(P<0.05),and the level of SOD was higher(P<0.05). Conclusion:The therapy of Jiangzhi Hugan tang can effectively reduce the oxidative stress responses in patients with MASH,enhance the anti-oxidative stress ability,improve the clinical symptoms,and has a good effect of liver protection and enzyme reduction and improving the level of blood lipid.

关 键 词：代谢相关脂肪性肝炎 降脂护肝汤 抗氧化 肝功能 中医证候积分 

分 类 号：R259[医药卫生—中西医结合]