续断接骨汤治疗闭合性四肢骨折临床研究  

Clinical Study on Xuduan Jiegu Tang for Closed Fracture of Limbs

作　　者：焦永伟 王嵩峰[1] 彭庆州[1] JIAO Yongwei;WANG Songfeng;PENG Qingzhou

机构地区：[1]郑州市骨科医院正骨科,河南郑州450000

出　　处：《新中医》2022年第19期125-129,共5页New Chinese Medicine

摘　　要：目的:观察续断接骨汤对闭合性四肢骨折患者胰岛素样生长因子-1(IGF-1)、骨形态发生蛋白-2(BMP-2)及血清T淋巴细胞亚群水平的影响。方法:将115例闭合性四肢骨折患者依据不同的治疗方法分为常规组和中药组。常规组57例行常规治疗,中药组58例在常规治疗的基础上加用续断接骨汤治疗。比较2组临床疗效、血清骨代谢产物、血清T淋巴细胞亚群、血液流变学指标及并发症发生情况。结果:中药组总有效率93.10%,高于常规组77.19%(P<0.05)。与同组治疗前比较,治疗后2组骨钙素(BGP)、IGF-1、BMP-2、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均升高(P<0.05),全血高切黏度、全血中切黏度、全血低切黏度均降低(P<0.05);与常规组治疗后比较,中药组治疗后BGP、IGF-1、BMP-2、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均较高(P<0.05),全血高切黏度、全血中切黏度、全血低切黏度均较低(P<0.05)。2组并发症发生率比较,差异无统计学意义(P>0.05)。结论:续断接骨汤治疗闭合性四肢骨折患者,可通过促使血小板黏附和红细胞聚集降低,调节血液流变学指标,改善疼痛肿胀症状,调控骨代谢水平,调节免疫功能,以提高临床疗效,且有较高的安全性。Objective:To observe the effect of Xuduan Jiegu tang on the levels of insulin-like growth factor-1(IGF-1),bone morphogenetic protein-2(BMP-2)and serum T lymphocyte subsets in patients with closed fracture of limbs.Methods:A total of 115 cases of patients with closed fracture of limbs were divided into the routine group and the Chinese medicine group according to different treatment methods,with 57 and 58 cases in each group respectively.The routine group was given routine treatment,and the Chinese medicine group was additionally treated with Xuduan Jiegu tang based on routine treatment.The clinical effects,serum bone metabolites,serum T lymphocyte subsets,hemorheology indexes and incidence of complications in the two groups were compared.Results:The total effective rate was 93.10%in the Chinese medicine group,higher than that of 77.19%in the routine group(P<0.05).After treatment,the levels of bone gla protein(BGP),IGF-1,BMP-2,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the two groups were increased when compared with those before treatment(P<0.05),and whole blood high shear viscosity,whole blood middle shear viscosity and whole blood low shear viscosity were decreased(P<0.05);the levels of BGP,IGF-1,BMP-2,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the Chinese medicine group were higher than those in the routine group(P<0.05),and whole blood high shear viscosity,whole blood middle shear viscosity and whole blood low shear viscosity were lower(P<0.05).There was no significant difference being found in the comparison of the incidence of complications between the two groups(P>0.05).Conclusion:Xuduan Jiegu tang for patients with closed fracture of limbs can improve the clinical effect withhigh safety by promoting the reduction of platelet adhesion and red blood cell aggregation, regulatinghemorheology indexes and immune function, improving pain and swelling, and controlling bonemetabolism levels.

关 键 词：闭合性四肢骨折 续断接骨汤 T淋巴细胞亚群 骨代谢 血液流变学 

分 类 号：R687.3[医药卫生—骨科学] R259[医药卫生—外科学]