接骨七厘胶囊联合复方骨肽注射液治疗四肢骨折临床研究  

Clinical Study on Jiegu Qili Capsules Combined with Compound Bone Peptide Injection for Limb Fracture

作　　者：王恒 陈霄 王家辉[1] WANG Heng;CHEN Xiao;WANG Jiahui

机构地区：[1]台州骨伤医院创伤骨科,浙江台州317500 [2]台州市中心医院(台州学院附属医院)肾内科,浙江台州318000

出　　处：《新中医》2022年第20期91-94,共4页New Chinese Medicine

摘　　要：目的:观察接骨七厘胶囊联合复方骨肽注射液治疗四肢骨折的临床疗效。方法:选取76例四肢骨折患者,采用随机数字表法分为观察组和对照组各38例,其中对照组剔除1例,最终纳入37例。2组均接受相同的内固定手术治疗,术后对照组使用复方骨肽注射液治疗,观察组在对照组基础上加用接骨七厘胶囊治疗。2组均治疗4周。比较2组临床疗效、症状评分、骨痂骨密度值及生长因子[转化生长因子-β1(TGF-β1)、碱性成纤维细胞生长因子(bFGF)、骨形成蛋白-2(BMP-2)]水平。结果:观察组总有效率94.74%,高于对照组75.68%(P<0.05)。治疗后,2组疼痛、肿胀、瘀斑评分均较治疗前降低(P<0.05),与对照组比较,观察组疼痛、肿胀、瘀斑评分均降低更明显(P<0.05)。治疗后,2组骨痂骨密度值均较治疗前增加(P<0.05),与对照组比较,观察组骨痂骨密度值增加更明显(P<0.05)。治疗后,2组TGF-β1、bFGF、BMP-2水平均较治疗前升高(P<0.05),观察组TGF-β1、b FGF、BMP-2水平均高于对照组(P<0.05)。结论:接骨七厘胶囊联合复方骨肽注射液治疗四肢骨折疗效较好,能够有效缓解临床症状,提升骨折愈合强度及生长因子的表达。Objective:To observe the clinical effect of Jiegu Qili capsules combined with compound bone peptide injection for limb fracture.Methods:A total of 76 cases of patients with limb fracture were selected and divided into the observation group and the control group according to the random number table method,with 38 cases in each group,one case in the control group was eliminated,at last 37 cases were intake.Both groups were given the same internal fixation for treatment;after operation,the control group was treated with compound bone peptide injection,and the observation group was additionally treated with Jiegu Qili capsules based on the treatment of the control group.Both groups were treated for four weeks.The clinical effects,the symptom scores,the bone mineral density of callus and the levels of growth factors including transforming growth factor-β1(TGF-β1),basic fibroblast growth factor(bFGF)and bone morphogenetic protein-2(BMP-2)in the two groups were compared.Results:The total effective rate was 94.74%in the observation group,higher than that of 75.68%in the control group(P<0.05).After treatment,the scores of pain,swelling and ecchymosis in the two groups were decreased when compared with those before treatment(P<0.05),and the scores of pain,swelling and ecchymosis in the observation group were significantly decreased when compared with those in the control group(P<0.05).After treatment,the bone mineral density of callus in the two groups were increased when compared with those before treatment(P<0.05),and the bone mineral density of callus in the observation group was significantly increased when compared with that in the control group(P<0.05).After treatment,the levels of TGF-β1,bFGF and BMP-2 in the two groups were increased when compared with those before treatment(P<0.05),and the levels of TGF-β1,bFGF and BMP-2 in the observation group were higher than those in the control group(P<0.05).Conclusion:Jiegu Qili capsules combined with compound bone peptide injection has a good curative effect in treating

关 键 词：四肢骨折 接骨七厘胶囊 复方骨肽注射液 症状评分 骨痂骨密度 转化生长因子-β1 碱性成纤维细胞生长因子 骨形成蛋白-2 

分 类 号：R683.4[医药卫生—骨科学]