小儿肺热咳喘颗粒治疗痰热阻肺证小儿毛细支气管炎临床研究  

Clinical Study on Xiao’Er Feire Kechuan Granules for Children with Bronchiolitis with Syndrome of Phlegm-Heat Obstructing the Lung

作　　者：朱伟峰 王超海 ZHU Weifeng;WANG Chaohai

机构地区：[1]绍兴文理学院附属医院小儿内科,浙江绍兴312000 [2]绍兴文理学院附属医院药剂科,浙江绍兴312000

出　　处：《新中医》2022年第20期107-110,共4页New Chinese Medicine

摘　　要：目的:观察小儿肺热咳喘颗粒治疗痰热阻肺证小儿毛细支气管炎的临床疗效。方法:选取痰热阻肺证毛细支气管炎患儿62例,按照随机数字表法分为治疗组和对照组各31例。对照组采取抗菌、抗炎、平喘等西医常规治疗措施;治疗组在对照组的基础上给予小儿肺热咳喘颗粒口服。2组均连续治疗1周。比较2组临床疗效及症状体征消失时间,以及治疗前后肺功能潮气量(TV)、顺应性(Crs)、功能残气量(FRC)水平变化。结果:治疗组总有效率为96.77%,对照组为74.19%,2组比较,差异有统计学意义(P<0.05)。治疗后,治疗组患儿咳嗽、喘息、哮鸣音、三凹征的消失时间均明显短于对照组(P<0.05)。治疗前,2组TV、Crs、FRC水平比较,差异无统计学意义(P>0.05)。治疗后,2组TV、Crs水平均较治疗前升高(P<0.05),而FRC水平较治疗前降低(P<0.05);且治疗组3项肺功能指标改善均优于对照组(P<0.05)。结论:小儿肺热咳喘颗粒联合西医常规治疗痰热阻肺证小儿毛细支气管炎,能促进患儿症状体征改善,提高肺功能,临床疗效肯定。Objective:To observe the clinical effect of the therapy of Xiao’er Feire Kechuan granules on children with bronchiolitis with syndrome of phlegm-heat obstructing the lung.Methods:A total of 62children with bronchiolitis with syndrome of phlegm-heat obstructing the lung were selected and divided into the treatment group and the control group according to random number table method,with 31 cases in each group.The control group received conventional western medicine treatment measures such as antibacterial,anti-inflammatory and antiasthmatic,and the treatment group was additionally given Xiao’er Feire Kechuan granules orally based on the treatment of the control group.Both groups were treated for one week.The clinical effects,disappearance time of symptoms and signs,and levels of lung function indexes,including tidal volume(TV),compliance of the respiratory system(Crs)and functional residual capacity(FRC)before and after treatment were compared between the two groups.Results:The total effective rate was 96.77%in the treatment group and 74.19%in the control group,the difference being significant(P<0.05).After treatment,the disappearance time of cough,panting,wheeze sound and three concave signs in the treatment group was significantly shorter than that in the control group(P<0.05).Before treatment,there was no significant difference in the levels of TV,Crs and FRC between the two groups(P>0.05).After treatment,the levels of TV and Crs in the two groups were increased when compared with those before treatment(P<0.05),and the FRC levels were decreased(P<0.05);the improvement of the above three lung function indexes in the treatment group was better than that in the control group(P<0.05).Conclusion:The therapy of Xiao’er Feire Kechuan granules for children with bronchiolitis with syndrome of phlegm-heat obstructing the lung can improve the symptoms and signs of children,enhance lung function,and has definite clinical effect.

关 键 词：小儿毛细支气管炎 小儿肺热咳喘颗粒 痰热阻肺证 肺功能 

分 类 号：R725.6[医药卫生—儿科]