乳腺增生症患者焦虑抑郁水平的中西医影响因素分析  

Analysis on the Influence Factors of Traditional Chinese and Western Medicine on Depression and Anxiety Level in Patients with Breast Hyperplasia

作　　者：乔楠[1] 陶晔 吴金娜[1] 方勇[1] 倪毓生[1] 丁晓雯[1] QIAO Nan;TAO Ye;WU Jinna;FANG Yong;NI Yusheng;DING Xiaowen(Nantong Hospital of Traditional Chinese Medicine,Nantong Jiangsu 226001,China)

机构地区：[1]南通市中医院,江苏南通226001

出　　处：《中医药导报》2022年第11期83-87,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：南通市科技局科技计划项目(JC2020004);南通市中医医疗联盟课题(TZYK201806)。

摘　　要：目的:研究乳腺增生症患者的焦虑抑郁水平与中西医影响因素的相关性。方法:选取乳腺增生症患者180例,采集患者年龄、病程、焦虑抑郁积分、症状积分、激素水平[雌二醇(E_(2))、孕酮(P)、催乳素(PRL)]、超声血流动力学指标[最大血流速度(V_(max))、最小血流速度(V_(min))、血流阻力指数(RI)]。按中医辨证标准分为血瘀痰凝证组、肝郁气滞证组和冲任失调证组,比较3组间焦虑抑郁积分;以单因素分析筛选出影响焦虑抑郁水平的影响因素,以多因素分析筛选出独立影响因素。结果:肝郁气滞证组患者焦虑抑郁积分明显高于血瘀痰凝证组和冲任失调证组,差异有统计学意义(P<0.05),血瘀痰凝证组患者焦虑抑郁积分高于冲任失调证组,差异有统计学意义(P<0.05);Pearson相关性分析结果显示发病时间、症状积分与焦虑抑郁积分之间呈正相关(P<0.05);E2与焦虑抑郁积分之间呈正相关(P<0.05),但相关性较弱;V_(min)与焦虑抑郁积分之间呈负相关(P<0.05),但相关性较弱。多元线性回归分析显示病程及症状积分为乳腺增生症患者焦虑抑郁水平的独立影响因素(P<0.05)。结论:肝郁气滞证乳腺增生症患者比血瘀痰凝证和冲任失调证患者更易产生焦虑抑郁,发病时间和临床症状是引起焦虑抑郁的独立影响因素,需受到临床更多的关注。Objective:To study the correlation between the anxiety-depression level of patients with breast hyperplasia and the influencing factors of Chinese and Western medicine.Methods:180 patients with breast hyperplasia were selected to collect their age,course of disease,anxiety-depression scores,clinical symptom scores,hormone levels(estradiol,progesterone,prolactin),ultrasound hemodynamic indicators(maximum blood flow velocity,minimum blood flow velocity and blood flow resistance index).The patients were divided into blood-stasis and phlegm-coagulation group,liver-stagnation and qi-stagnation group and Chongren disorder group,according to the standard of TCM differentiation.The anxiety-depression scores among the three groups were compared.The influencing factors of anxiety and depression were screened by single factor analysis,and the independent influencing factors were screened by multi factor analysis.Results:The anxiety-depression score of the liver-stagnation and qi-stagnation group was significantly higher than that of the other two groups,and the difference was statistically significant(P<0.05).The anxiety-depression score of the blood-stasis and phlegm-coagulation group was higher than that of the Chongren disorder group,and the difference was statistically significant significance(P<0.05).The results of Pearson correlation analysis showed that the course of disease,symptom scores were positively correlated with anxiety and depression scores,and the correlation was strong(P<0.05).E_(2) was positively correlated with anxiety and depression scores,and the correlation was weak(P<0.05).The Vmin is negatively correlated,and the correlation is weak(P<0.05).Multiple linear regression analysis showed that the course of disease and symptom score were independent influencing factors of anxiety-depression level in mammary hyperplasa patients(P<0.05).Conclusion:Patients with liver-stagnation and qi-stagnation syndrome of breast hyperplasia are more likely to produce anxiety and depression than blood-stasis and phlegm-co

关 键 词：乳腺增生症 焦虑抑郁 中医辨证 肝郁气滞证 血瘀痰凝证 冲任失调证 影响因素 相关分析 

分 类 号：R271.9[医药卫生—中西医结合]