痰浊蒙窍型轻度认知功能障碍(MCI)的认知损害特点及血清Hcy、GHb、尿AD7c-NTP表达水平相关性研究  

Study on the Characteristics of Cognitive Impairment and the Correlation between Serum Hcy, Ghb and Urinary Ad7C Ntp Expression in Patients with Phlegm Turbidity and Orifices (MCI)

作　　者：庞敬涛[1] 刘娟[1] 孙丽[1] 商珍珠 PANG Jingtao;LIU Juan;SUN Li;SHANG Zhenzhu(Weifang Hospital of Traditional Chinese Medicine,Weifang 261041,Shandong,China)

机构地区：[1]潍坊市中医院,山东潍坊261041

出　　处：《实用中医内科杂志》2022年第9期123-125,共3页Journal of Practical Traditional Chinese Internal Medicine

基　　金：潍坊市中医药科研项目(2021-4-059)。

摘　　要：目的 探讨痰浊蒙窍型轻度认知功能障碍(MCI)患者的认知功能受损的特点,血清同型半胱氨酸(Hcy)及阿尔茨海默病相关神经丝蛋白(AD7c-NTP)表达水平与痰浊蒙窍证轻度认知功能损害的相关性。方法 选取潍坊市中医院脑病科2015年1月—2020年12月收治的痰浊蒙窍型MCI患者120例;依照“血管性痴呆诊断、辨证及疗效评定标准”拟定MCI中医辨证分型量表,筛选“痰浊蒙窍证”48例为观察组,其他证型72例为对照组;比较两组相关危险的因素,包括年龄、性别、教育程度、吸烟、饮酒、高血压病、糖尿病、高脂血症、心脏病、脑血管疾病及家族史;检测相关的临床理化指标,包括GHb、血脂、Hcy、尿AD7c-NTP;分析痰浊蒙窍型MCI患者认知损害特点及相关因素、理化指标与MoCA评分的相关性。结果 两组在年龄、性别、教育程度、吸烟、饮酒、高血压病、心脏病、脑血管疾病等临床资料比较,差异无统计学意义(P>0.05);两组LDL-C,TC,TG,GHb, Hcy, AD7c-NTP、MoCA评分比较,差异有统计学意义(P<0.05);GHb、血清Hcy、尿AD7c-NTP水平与MoCA评分存在明显相关性,痰浊蒙窍型MCI患者的中医症候评分与Hcy、尿AD7c-NTP水平、MoCA评分密切相关。结论 MCI患者的认知损害特点主要表现在注意力、语言表达、延迟回忆方面;痰浊蒙窍型MCI患者的GHb、血清Hcy、尿AD7c-NTP水平与MoCA评分呈负相关;检测血清Hcy、GHb、尿AD7c-NTP水平有助于痰浊蒙窍型MCI患者的诊断、预防提供依据。Objective To investigate the characteristics of cognitive impairment in patients with mild cognitive impairment(MCI);The correlation between serum homocysteine(Hcy) and Alzheimer’s disease-related neurofilament protein(AD7 C NTP) expression levels and mild cognitive impairment of phlegm turbid orifices syndrome.Methods 120 patients with MCI were selected from the Department of encephalopathy of Weifang Hospital of Traditional Chinese Medicine from January 2015 to January 2020,according to the standard of diagnosis, syndrome differentiation and curative effect evaluation of vascular dementia, the MCI scale of traditional Chinese medicine syndrome differentiation was drawn up. 48 cases of "phlegm turbid orifices" were selected as the observation group, and 72 cases of other syndrome types were selected as the control group;The risk factors of the 2 groups were compared, including age, gender, education, smoking, drinking, hypertension, diabetes, hyperlipidemia, heart disease, cerebrovascular disease and family history. The related clinical physical and chemical indexes were detected low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C), total cholesterol(TC), triglyceride(TG), glycosylated hemoglobin(GHB), Hcy and urine AD7 C NTP,the correlation between MOCA score and the characteristics of cognitive impairment and related factors, physical and chemical indexes in patients with phlegm turbidity and orifices.Results There was no significant difference in age, gender, education, smoking, drinking, hypertension, heart disease, cerebrovascular disease and other clinical data between the two groups(P > 0.05),there were significant differences in LDL-C, TC, TG, GHB, Hcy, AD7 C NTP and MOCA scores(attention, language and delayed memory) between the two groups(P<0.05),the correlation analysis showed that GHB, serum Hcy and urine AD7 C NTP levels were significantly correlated with MOCA score.Conclusion The cognitive impairment of MCI patients with spleen deficiency and phlegm turbidity sy

关 键 词：认知功能障碍 痰浊蒙窍 血清HCY GHB 尿AD7c-NTP MoCA评分 

分 类 号：R289.1[医药卫生—方剂学]