中医药调节代谢类疾病Th17/Treg免疫平衡的研究进展  

Research Progress on Traditional Chinese Medicine Regulating Th17/Treg Immune Balance in Metabolic Diseases

作　　者：田野 高泓[1,2] 谢春光 TIAN Ye;GAO Hong;XIE Chunguan(Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan,China;Traditional Chinese Medicine Regulating Metabolic Diseases Key Laboratory of Sichuan Province,Chengdu 610075,Sichuan,China)

机构地区：[1]成都中医药大学附属医院,四川成都610075 [2]代谢性疾病中医药调控四川省重点实验室,四川成都610075

出　　处：《中华中医药学刊》2022年第9期180-183,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金(81774302)。

摘　　要：代谢类疾病是肥胖、免疫异常、遗传等多种因素共同作用引起的以碳水化合物、脂质、蛋白质等营养物质代谢异常为特征的疾病,属于重大公共卫生问题之一。代谢类疾病的发病机制未完全明确,近年来认为核心机制之一为慢性系统性微炎症免疫炎症反应,其中调节性T细胞(Treg)以及辅助性T细胞17(Th17)发挥着重要作用,而调节Th17/Treg平衡成为代谢类疾病防治的新靶点。就2型糖尿病(T2DM)、肥胖、非酒精性脂肪肝(NAFLD)3种常见代谢类疾病与Th17/Treg平衡的关系,以及中医药对各病Th17/Treg免疫平衡的影响进行综述,以期为中医药防治代谢类疾病提供新思路。Metabolic diseases are diseases characterized by abnormal metabolism of nutrients such as carbohydrates,lipids and proteins caused by obesity,immune abnormalities,heredity and other factors.They belong to one of the major public health problems.The pathogenesis of metabolic diseases is not completely clear.In recent years,one of the core mechanisms is chronic systemic inflammatory microinflammatory immune response,andregulatory T cells(Treg)and helper T cells 17(Th17)play an important role.Regulating Th17/Treg balance has become a new target for the prevention and treatment of metabolic diseases.This paper reviewed the relationship among the three common metabolic diseases of type 2 diabetes mellitus(T2 DM),obesity and non-alcoholic fatty liver disease(NAFLD)and Th17/Treg balanceas well as the influence of traditional Chinese medicine on Th17/Treg immune balance,in order to provide new thinking for traditional Chinese medicine to prevent metabolic diseases.

关 键 词：中医药 代谢类疾病 辅助性T细胞17/调节性T细胞平衡 免疫 综述 

分 类 号：R259.89[医药卫生—中西医结合]